Cell Senescence Entries for PIR
- Cell Types
- Melanoma
- Cell Lines
- IGR37, WM266-4
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced, Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Licciulli et al. (2011) Pirin inhibits cellular senescence in melanocytic cells. Am J Pathol 178(5)2397-406 (PubMed)
PIR Gene Information
- HGNC symbol
- PIR
- Aliases
- Common name
- pirin
- Entrez Id
- 8544
- Description
- This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
PIR Ontologies
- Gene Ontology
-
Process: GO:30099; myeloid cell differentiation
GO:6355; regulation of transcription, DNA-templated
GO:6366; transcription by RNA polymerase II
GO:30224; monocyte differentiation
GO:7586; digestion
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5654; nucleoplasm
Hide GO termsFunction: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:3712; transcription coregulator activity
GO:8127; quercetin 2,3-dioxygenase activity
Homologs of PIR in Model Organisms
External links
- OMIM
- 300931
- Ensembl
- ENSG00000087842
- Entrez Gene
- 8544
- UniGene
- 732521
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PIR
- GeneCards
- PIR