Cell Senescence Entries for PLA2G2A

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Augert et al. (2009) The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO Rep 10(3)271-7 (PubMed)

PLA2G2A Gene Information

HGNC symbol
PLA2G2A 
Aliases
PLA2B; PLA2L 
Common name
phospholipase A2 group IIA 
Entrez Id
5320
Description
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009].

PLA2G2A Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6644; phospholipid metabolic process
GO:8152; metabolic process
GO:6954; inflammatory response
GO:6654; phosphatidic acid biosynthetic process
GO:16042; lipid catabolic process
GO:36148; phosphatidylglycerol acyl-chain remodeling
GO:36149; phosphatidylinositol acyl-chain remodeling
GO:36150; phosphatidylserine acyl-chain remodeling
GO:36151; phosphatidylcholine acyl-chain remodeling
GO:36152; phosphatidylethanolamine acyl-chain remodeling
GO:50482; arachidonic acid secretion
GO:50830; defense response to Gram-positive bacterium
GO:42742; defense response to bacterium
GO:19835; cytolysis
GO:50729; positive regulation of inflammatory response
GO:10744; positive regulation of macrophage derived foam cell differentiation
GO:46337; phosphatidylethanolamine metabolic process
GO:46470; phosphatidylcholine metabolic process
GO:34374; low-density lipoprotein particle remodeling
GO:36335; intestinal stem cell homeostasis
GO:46473; phosphatidic acid metabolic process
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:1902563; regulation of neutrophil activation
Cellular component: GO:5615; extracellular space
GO:16020; membrane
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:5576; extracellular region
GO:5789; endoplasmic reticulum membrane
GO:70062; extracellular exosome
GO:5783; endoplasmic reticulum
GO:30141; secretory granule
GO:48471; perinuclear region of cytoplasm
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:5509; calcium ion binding
GO:3824; catalytic activity
GO:4623; phospholipase A2 activity
GO:5543; phospholipid binding
GO:47498; calcium-dependent phospholipase A2 activity
Hide GO terms

Homologs of PLA2G2A in Model Organisms

Mus musculus
Pla2g2a
Rattus norvegicus
Pla2g2a

External links

OMIM
172411
Ensembl
ENSG00000188257
Entrez Gene
5320
UniGene
466804
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PLA2G2A
GeneCards
PLA2G2A