Cell Senescence Entries for PLA2R1
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90, WI-38
- Cancer Cell?
- No
- Method
- Knockout, Overexpression
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Augert et al. (2009) The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO Rep 10(3)271-7 (PubMed)
PLA2R1 Gene Information
- HGNC symbol
- PLA2R1
- Aliases
- CLEC13C; PLA2-R; PLA2G1R; PLA2IR
- Common name
- phospholipase A2 receptor 1
- Entrez Id
- 22925
- Description
- This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
PLA2R1 Ontologies
- Gene Ontology
-
Process: GO:6897; endocytosis
GO:72593; reactive oxygen species metabolic process
GO:1819; positive regulation of cytokine production
GO:90403; oxidative stress-induced premature senescence
GO:43517; positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:6898; receptor-mediated endocytosis
GO:1904635; positive regulation of glomerular visceral epithelial cell apoptotic process
GO:90399; replicative senescence
GO:1900138; negative regulation of phospholipase A2 activity
GO:90238; positive regulation of arachidonic acid secretion
GO:1900139; negative regulation of arachidonic acid secretion
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:9986; cell surface
GO:5887; integral component of plasma membrane
GO:43235; receptor complex
Hide GO termsFunction: GO:30246; carbohydrate binding
GO:38023; signaling receptor activity
GO:43274; phospholipase binding
Homologs of PLA2R1 in Model Organisms
- Danio rerio
- uncharacterized_E7FB
- Mus musculus
- Pla2r1
- Rattus norvegicus
- Pla2r1
External links
- OMIM
- 604939
- Ensembl
- ENSG00000153246
- Entrez Gene
- 22925
- UniGene
- 410477
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PLA2R1
- GeneCards
- PLA2R1