Cell Senescence Entries for PLD2

Cell Types
Colorectal cancer, Lung fibroblast
Cell Lines
HCT116, IMR-90
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2014) Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species-p53-p21Cip1/WAF1 pathway. FEBS Lett 588(17)3251-8 (PubMed)

PLD2 Gene Information

HGNC symbol
PLD2 
Aliases
 
Common name
phospholipase D2 
Entrez Id
5338
Description
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].

PLD2 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:16042; lipid catabolic process
GO:7264; small GTPase mediated signal transduction
GO:36465; synaptic vesicle recycling
GO:6654; phosphatidic acid biosynthetic process
GO:7010; cytoskeleton organization
GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:48017; inositol lipid-mediated signaling
GO:48870; cell motility
Cellular component: GO:16020; membrane
GO:5886; plasma membrane
GO:98793; presynapse
GO:5789; endoplasmic reticulum membrane
Function: GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:35091; phosphatidylinositol binding
GO:4630; phospholipase D activity
GO:70290; N-acylphosphatidylethanolamine-specific phospholipase D activity
Hide GO terms

Homologs of PLD2 in Model Organisms

Caenorhabditis elegans
pld-1
Danio rerio
pld2
Mus musculus
Pld2
Rattus norvegicus
Pld2
Saccharomyces cerevisiae
SPO14

External links

OMIM
602384
Ensembl
ENSG00000129219
Entrez Gene
5338
UniGene
104519
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PLD2
GeneCards
PLD2