Cell Senescence Entries for PLK1

Cell Types
Dermal fibroblast, Umbilical vein endothelial
Cell Lines
HUVEC, Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2013) Downregulation of Polo-like kinase 1 induces cellular senescence in human primary cells through a p53-dependent pathway. J Gerontol A Biol Sci Med Sci 68(10)1145-56 (PubMed)

PLK1 Gene Information

HGNC symbol
PLK1 
Aliases
PLK 
Common name
polo like kinase 1 
Entrez Id
5347
Description
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015].

PLK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:16567; protein ubiquitination
GO:51301; cell division
GO:122; negative regulation of transcription by RNA polymerase II
GO:18105; peptidyl-serine phosphorylation
GO:132; establishment of mitotic spindle orientation
GO:31648; protein destabilization
GO:1578; microtubule bundle formation
GO:278; mitotic cell cycle
GO:7098; centrosome cycle
GO:7346; regulation of mitotic cell cycle
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:32465; regulation of cytokinesis
GO:1904668; positive regulation of ubiquitin protein ligase activity
GO:281; mitotic cytokinesis
GO:86; G2/M transition of mitotic cell cycle
GO:10800; positive regulation of peptidyl-threonine phosphorylation
GO:45862; positive regulation of proteolysis
GO:7094; mitotic spindle assembly checkpoint signaling
GO:70; mitotic sister chromatid segregation
GO:71168; protein localization to chromatin
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:7077; mitotic nuclear membrane disassembly
GO:45184; establishment of protein localization
GO:51443; positive regulation of ubiquitin-protein transferase activity
GO:43393; regulation of protein binding
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:1905784; regulation of anaphase-promoting complex-dependent catabolic process
GO:51726; regulation of cell cycle
GO:7052; mitotic spindle organization
GO:7062; sister chromatid cohesion
GO:7076; mitotic chromosome condensation
GO:16321; female meiosis chromosome segregation
GO:30071; regulation of mitotic metaphase/anaphase transition
GO:33365; protein localization to organelle
GO:45143; homologous chromosome segregation
GO:51081; nuclear membrane disassembly
GO:70194; synaptonemal complex disassembly
GO:90435; protein localization to nuclear envelope
GO:1900182; positive regulation of protein localization to nucleus
GO:1901673; regulation of mitotic spindle assembly
GO:1901990; regulation of mitotic cell cycle phase transition
GO:1904776; regulation of protein localization to cell cortex
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:5815; microtubule organizing center
GO:5819; spindle
GO:776; kinetochore
GO:30496; midbody
GO:5813; centrosome
GO:5654; nucleoplasm
GO:5829; cytosol
GO:922; spindle pole
GO:51233; spindle midzone
GO:940; outer kinetochore
GO:5876; spindle microtubule
GO:15630; microtubule cytoskeleton
GO:779; condensed chromosome, centromeric region
GO:785; chromatin
GO:795; synaptonemal complex
GO:5814; centriole
GO:34451; centriolar satellite
GO:97431; mitotic spindle pole
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:5524; ATP binding
GO:5515; protein binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:8017; microtubule binding
GO:42802; identical protein binding
GO:19901; protein kinase binding
GO:287; magnesium ion binding
GO:10997; anaphase-promoting complex binding
Hide GO terms

Homologs of PLK1 in Model Organisms

Caenorhabditis elegans
plk-2
Danio rerio
plk1
Drosophila melanogaster
polo
Mus musculus
Plk1
Rattus norvegicus
Plk1

In other databases

CellAge gene expression
  • This gene is present as PLK1

External links

OMIM
602098
Ensembl
ENSG00000166851
Entrez Gene
5347
UniGene
592049
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PLK1
GeneCards
PLK1