Cell Senescence Entries for PML

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Pearson et al. (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406(6792)207-10 (PubMed)

PML Gene Information

HGNC symbol
PML 
Aliases
MYL; RNF71; TRIM19 
Common name
PML nuclear body scaffold 
Entrez Id
5371
Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

PML Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:16567; protein ubiquitination
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:48511; rhythmic process
GO:16925; protein sumoylation
GO:32922; circadian regulation of gene expression
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:51726; regulation of cell cycle
GO:50821; protein stabilization
GO:30308; negative regulation of cell growth
GO:1666; response to hypoxia
GO:16525; negative regulation of angiogenesis
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:6605; protein targeting
GO:51974; negative regulation of telomerase activity
GO:65003; protein-containing complex assembly
GO:42752; regulation of circadian rhythm
GO:8285; negative regulation of cell population proliferation
GO:1932; regulation of protein phosphorylation
GO:90398; cellular senescence
GO:31065; positive regulation of histone deacetylation
GO:42771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:43153; entrainment of circadian clock by photoperiod
GO:2001238; positive regulation of extrinsic apoptotic signaling pathway
GO:2000059; negative regulation of ubiquitin-dependent protein catabolic process
GO:44790; negative regulation by host of viral release from host cell
GO:32206; positive regulation of telomere maintenance
GO:34097; response to cytokine
GO:32469; endoplasmic reticulum calcium ion homeostasis
GO:51457; maintenance of protein location in nucleus
GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:10522; regulation of calcium ion transport into cytosol
GO:30578; PML body organization
GO:2000779; regulation of double-strand break repair
GO:32211; negative regulation of telomere maintenance via telomerase
GO:32938; negative regulation of translation in response to oxidative stress
GO:60058; positive regulation of apoptotic process involved in mammary gland involution
GO:1904816; positive regulation of protein localization to chromosome, telomeric region
GO:6606; protein import into nucleus
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:7179; transforming growth factor beta receptor signaling pathway
GO:7182; common-partner SMAD protein phosphorylation
GO:8631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:9411; response to UV
GO:10332; response to gamma radiation
GO:10761; fibroblast migration
GO:30099; myeloid cell differentiation
GO:30155; regulation of cell adhesion
GO:32691; negative regulation of interleukin-1 beta production
GO:32692; negative regulation of interleukin-1 production
GO:45165; cell fate commitment
GO:48146; positive regulation of fibroblast proliferation
GO:48384; retinoic acid receptor signaling pathway
GO:60444; branching involved in mammary gland duct morphogenesis
GO:70059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:71353; cellular response to interleukin-4
GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator
GO:90402; oncogene-induced cell senescence
GO:97191; extrinsic apoptotic signaling pathway
GO:1901798; positive regulation of signal transduction by p53 class mediator
GO:1990830; cellular response to leukemia inhibitory factor
GO:2000758; positive regulation of peptidyl-lysine acetylation
GO:2001235; positive regulation of apoptotic signaling pathway
GO:2230; positive regulation of defense response to virus by host
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5768; endosome
GO:5829; cytosol
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:16605; PML body
GO:31901; early endosome membrane
GO:16363; nuclear matrix
GO:785; chromatin
GO:42406; extrinsic component of endoplasmic reticulum membrane
GO:792; heterochromatin
Function: GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3713; transcription coactivator activity
GO:4842; ubiquitin-protein transferase activity
GO:42803; protein homodimerization activity
GO:19789; SUMO transferase activity
GO:32183; SUMO binding
GO:140037; sumo-dependent protein binding
GO:42802; identical protein binding
GO:46332; SMAD binding
GO:50897; cobalt ion binding
Hide GO terms

Homologs of PML in Model Organisms

Mus musculus
Pml
Rattus norvegicus
Pml

In other databases

GenAge human genes
  • This gene is present as PML

External links

OMIM
102578
Ensembl
ENSG00000140464
Entrez Gene
5371
UniGene
654583
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PML
GeneCards
PML