Cell Senescence Entries for POT1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Yang et al. (2005) POT1 and TRF2 cooperate to maintain telomeric integrity. Mol Cell Biol 25(3)1070-80 (PubMed)

POT1 Gene Information

HGNC symbol
POT1 
Aliases
DKFZp586D211; hPot1 
Common name
protection of telomeres 1 
Entrez Id
25913
Description
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

POT1 Ontologies

Gene Ontology
Process: GO:723; telomere maintenance
GO:51276; chromosome organization
GO:32212; positive regulation of telomere maintenance via telomerase
GO:51973; positive regulation of telomerase activity
GO:7004; telomere maintenance via telomerase
GO:70200; establishment of protein localization to telomere
GO:32508; DNA duplex unwinding
GO:61820; telomeric D-loop disassembly
GO:32210; regulation of telomere maintenance via telomerase
GO:51974; negative regulation of telomerase activity
GO:32211; negative regulation of telomere maintenance via telomerase
GO:51096; positive regulation of helicase activity
GO:16233; telomere capping
GO:32206; positive regulation of telomere maintenance
GO:32202; telomere assembly
GO:60383; positive regulation of DNA strand elongation
GO:1905774; regulation of DNA helicase activity
GO:1905776; positive regulation of DNA helicase activity
GO:2001032; regulation of double-strand break repair via nonhomologous end joining
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:783; nuclear telomere cap complex
GO:70187; shelterin complex
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:43047; single-stranded telomeric DNA binding
GO:61821; telomeric D-loop binding
GO:98505; G-rich strand telomeric DNA binding
GO:42162; telomeric DNA binding
GO:1905773; 8-hydroxy-2'-deoxyguanosine DNA binding
GO:17151; DEAD/H-box RNA helicase binding
GO:10521; telomerase inhibitor activity
GO:1990955; G-rich single-stranded DNA binding
Hide GO terms

Homologs of POT1 in Model Organisms

Danio rerio
pot1
Mus musculus
Pot1
Rattus norvegicus
Pot1b
Schizosaccharomyces pombe
pot1

In other databases

LongevityMap
  • This gene is present as POT1

External links

OMIM
606478
Ensembl
ENSG00000128513
Entrez Gene
25913
UniGene
31968
1000 Genomes
1000 Genomes
HPRD
GenAtlas
POT1
GeneCards
POT1