Cell Senescence Entries for PPARGC1A

Cell Types
Retinal pigment epithelial
Cell Lines
ARPE-19
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Roggia et al. (2016) αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium. PLoS One 10(8)e0134870 (PubMed)

PPARGC1A Gene Information

HGNC symbol
PPARGC1A 
Aliases
PGC-1alpha; PGC1; PGC1A; PPARGC1 
Common name
PPARG coactivator 1 alpha 
Entrez Id
10891
Description
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008].

PPARGC1A Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:6397; mRNA processing
GO:8380; RNA splicing
GO:6355; regulation of transcription, DNA-templated
GO:7005; mitochondrion organization
GO:48511; rhythmic process
GO:6094; gluconeogenesis
GO:32922; circadian regulation of gene expression
GO:2021; response to dietary excess
GO:10822; positive regulation of mitochondrion organization
GO:14850; response to muscle activity
GO:22904; respiratory electron transport chain
GO:34599; cellular response to oxidative stress
GO:42752; regulation of circadian rhythm
GO:43524; negative regulation of neuron apoptotic process
GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:60612; adipose tissue development
GO:97009; energy homeostasis
GO:120162; positive regulation of cold-induced thermogenesis
GO:1901857; positive regulation of cellular respiration
GO:1901860; positive regulation of mitochondrial DNA metabolic process
GO:1901863; positive regulation of muscle tissue development
GO:2001171; positive regulation of ATP biosynthetic process
GO:6367; transcription initiation from RNA polymerase II promoter
GO:7586; digestion
GO:50821; protein stabilization
GO:65003; protein-containing complex assembly
GO:1678; cellular glucose homeostasis
GO:45333; cellular respiration
GO:42594; response to starvation
GO:1659; temperature homeostasis
GO:46321; positive regulation of fatty acid oxidation
GO:48662; negative regulation of smooth muscle cell proliferation
GO:19395; fatty acid oxidation
GO:45722; positive regulation of gluconeogenesis
GO:1901215; negative regulation of neuron death
GO:50873; brown fat cell differentiation
GO:35066; positive regulation of histone acetylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:16605; PML body
GO:785; chromatin
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5102; signaling receptor binding
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3712; transcription coregulator activity
GO:31490; chromatin DNA binding
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:140297; DNA-binding transcription factor binding
GO:16922; nuclear receptor binding
GO:30374; nuclear receptor coactivator activity
GO:8134; transcription factor binding
Hide GO terms

Homologs of PPARGC1A in Model Organisms

Danio rerio
ppargc1a
Mus musculus
Ppargc1a
Rattus norvegicus
Ppargc1a

In other databases

GenAge human genes
LongevityMap

External links

OMIM
604517
Ensembl
ENSG00000109819
Entrez Gene
10891
UniGene
527078
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPARGC1A
GeneCards
PPARGC1A