Cell Senescence Entries for PPM1B

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Park et al. (2015) PPM1B depletion induces premature senescence in human IMR-90 fibroblasts. Mech Ageing Dev 138(2)45-52 (PubMed)

PPM1B Gene Information

HGNC symbol
PPM1B 
Aliases
PP2CB; PP2CBETA; PPC2BETAX 
Common name
protein phosphatase, Mg2+/Mn2+ dependent 1B 
Entrez Id
5495
Description
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008].

PPM1B Ontologies

Gene Ontology
Process: GO:6470; protein dephosphorylation
GO:1901223; negative regulation of NIK/NF-kappaB signaling
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:35970; peptidyl-threonine dephosphorylation
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:6499; N-terminal protein myristoylation
GO:32688; negative regulation of interferon-beta production
GO:50687; negative regulation of defense response to virus
GO:16311; dephosphorylation
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:110165; cellular anatomical entity
GO:5829; cytosol
GO:5730; nucleolus
GO:5634; nucleus
Function: GO:46872; metal ion binding
GO:287; magnesium ion binding
GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:16791; phosphatase activity
GO:30145; manganese ion binding
GO:43169; cation binding
GO:5515; protein binding
Hide GO terms

Homologs of PPM1B in Model Organisms

Danio rerio
ppm1bb
Mus musculus
Ppm1b
Rattus norvegicus
Ppm1b

External links

OMIM
603770
Ensembl
ENSG00000138032
Entrez Gene
5495
UniGene
416769
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPM1B
GeneCards
PPM1B