Cell Senescence Entries for PPM1D

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2010) Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways. Stem Cells 27(8)1963-75 (PubMed)

PPM1D Gene Information

HGNC symbol
PPM1D 
Aliases
PP2C-DELTA; Wip1 
Common name
protein phosphatase, Mg2+/Mn2+ dependent 1D 
Entrez Id
8493
Description
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].

PPM1D Ontologies

Gene Ontology
Process: GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:7049; cell cycle
GO:6468; protein phosphorylation
GO:86; G2/M transition of mitotic cell cycle
GO:6306; DNA methylation
GO:9267; cellular response to starvation
GO:9617; response to bacterium
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:31507; heterochromatin assembly
GO:8285; negative regulation of cell population proliferation
GO:9314; response to radiation
GO:35970; peptidyl-threonine dephosphorylation
GO:45814; negative regulation of gene expression, epigenetic
GO:60260; regulation of transcription initiation from RNA polymerase II promoter
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:4721; phosphoprotein phosphatase activity
GO:16791; phosphatase activity
GO:43169; cation binding
GO:4722; protein serine/threonine phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:5515; protein binding
GO:4674; protein serine/threonine kinase activity
GO:51019; mitogen-activated protein kinase binding
Hide GO terms

Homologs of PPM1D in Model Organisms

Danio rerio
ppm1db
Mus musculus
Ppm1d
Rattus norvegicus
Ppm1d

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Ppm1d
GenAge human genes
  • This gene is present as PPM1D

External links

OMIM
605100
Ensembl
ENSG00000170836
Entrez Gene
8493
UniGene
286073
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPM1D
GeneCards
PPM1D