The PPP1R13B gene and its putative association with human ageing

Cell Senescence Entries for PPP1R13B

Cell Types: Colon cancer
Cell Lines: HCT116
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Stress-induced
Senescence Effect: Inhibits
Primary Reference: Vigneron et al. (2012) An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence. EMBO J 31(2)471-80 (PubMed)

HGNC symbol: PPP1R13B
Aliases: ASPP1; KIAA0771; p53BP2-like; p85
Common name: protein phosphatase 1 regulatory subunit 13B
Entrez Id: 23368
Description: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:

GO:45786; negative regulation of cell cycle
GO:6915; apoptotic process
GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator

Cellular component:

GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5634; nucleus
GO:5737; cytoplasm

Function:

GO:5515; protein binding
GO:8134; transcription factor binding
GO:2039; p53 binding

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