Cell Senescence Entries for PPP2R1A

Cell Types
Lung cancer
Cell Lines
NCI-H460
Cancer Cell?
Yes
Method
Mutation
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Kauko et al. (2019) PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med 10(450)117-26 (PubMed)

PPP2R1A Gene Information

HGNC symbol
PPP2R1A 
Aliases
PP2A-Aalpha; PP2AA; PR65A 
Common name
protein phosphatase 2 scaffold subunit Aalpha 
Entrez Id
5518
Description
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].

PPP2R1A Ontologies

Gene Ontology
Process: GO:8380; RNA splicing
GO:6915; apoptotic process
GO:50790; regulation of catalytic activity
GO:6355; regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6470; protein dephosphorylation
GO:10033; response to organic substance
GO:7059; chromosome segregation
GO:6672; ceramide metabolic process
GO:65003; protein-containing complex assembly
GO:30111; regulation of Wnt signaling pathway
GO:30308; negative regulation of cell growth
GO:30155; regulation of cell adhesion
GO:7143; female meiotic nuclear division
GO:51232; meiotic spindle elongation
GO:51306; mitotic sister chromatid separation
GO:51754; meiotic sister chromatid cohesion, centromeric
GO:70262; peptidyl-serine dephosphorylation
GO:1903538; regulation of meiotic cell cycle process involved in oocyte maturation
GO:2001241; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:45595; regulation of cell differentiation
GO:42532; negative regulation of tyrosine phosphorylation of STAT protein
GO:43409; negative regulation of MAPK cascade
GO:6275; regulation of DNA replication
GO:19932; second-messenger-mediated signaling
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5829; cytosol
GO:5694; chromosome
GO:42995; cell projection
GO:30425; dendrite
GO:43005; neuron projection
GO:775; chromosome, centromeric region
GO:159; protein phosphatase type 2A complex
GO:16328; lateral plasma membrane
GO:15630; microtubule cytoskeleton
GO:70062; extracellular exosome
GO:45202; synapse
GO:98978; glutamatergic synapse
GO:43025; neuronal cell body
Function: GO:5515; protein binding
GO:19888; protein phosphatase regulator activity
GO:4722; protein serine/threonine phosphatase activity
GO:46982; protein heterodimerization activity
GO:1990405; protein antigen binding
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Homologs of PPP2R1A in Model Organisms

Mus musculus
Ppp2r1a
Rattus norvegicus
Ppp2r1a
Saccharomyces cerevisiae
TPD3

External links

OMIM
605983
Ensembl
ENSG00000105568
Entrez Gene
5518
UniGene
467192
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPP2R1A
GeneCards
PPP2R1A