Cell Senescence Entries for PPP2R5A

Cell Types
Melanoma
Cell Lines
SK-MEL-103, SK-MEL-147, SK-MEL-19, SK-MEL-29
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Mannava et al. (2012) PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells. Oncogene 31(12)1484-92 (PubMed)

PPP2R5A Gene Information

HGNC symbol
PPP2R5A 
Aliases
B56A; B56alpha; PR61A 
Common name
protein phosphatase 2 regulatory subunit B'alpha 
Entrez Id
5525
Description
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].

PPP2R5A Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:6470; protein dephosphorylation
GO:35307; positive regulation of protein dephosphorylation
GO:1903077; negative regulation of protein localization to plasma membrane
GO:90219; negative regulation of lipid kinase activity
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5829; cytosol
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:159; protein phosphatase type 2A complex
GO:5813; centrosome
GO:16020; membrane
GO:30018; Z disc
GO:31430; M band
Function: GO:4721; phosphoprotein phosphatase activity
GO:5515; protein binding
GO:19888; protein phosphatase regulator activity
GO:19900; kinase binding
GO:72542; protein phosphatase activator activity
Hide GO terms

Homologs of PPP2R5A in Model Organisms

Danio rerio
ppp2r5a
Drosophila melanogaster
wdb
Mus musculus
Ppp2r5a
Rattus norvegicus
Ppp2r5a

External links

OMIM
601643
Ensembl
ENSG00000066027
Entrez Gene
5525
UniGene
744012
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPP2R5A
GeneCards
PPP2R5A