Cell Senescence Entries for PRKAA2

Cell Types
Lung fibroblast, Umbilical vein endothelial
Cell Lines
HUVEC, MRC-5
Cancer Cell?
No
Method
Mutation
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Han et al. (2017) AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation. Aging Cell 15(3)416-27 (PubMed)

PRKAA2 Gene Information

HGNC symbol
PRKAA2 
Aliases
AMPK; AMPKa2; PRKAA 
Common name
protein kinase AMP-activated catalytic subunit alpha 2 
Entrez Id
5563
Description
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].

PRKAA2 Ontologies

Gene Ontology
Process: GO:10629; negative regulation of gene expression
GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6325; chromatin organization
GO:6629; lipid metabolic process
GO:6631; fatty acid metabolic process
GO:6633; fatty acid biosynthetic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:16126; sterol biosynthetic process
GO:16055; Wnt signaling pathway
GO:6914; autophagy
GO:48511; rhythmic process
GO:35556; intracellular signal transduction
GO:10508; positive regulation of autophagy
GO:7165; signal transduction
GO:32007; negative regulation of TOR signaling
GO:97009; energy homeostasis
GO:42752; regulation of circadian rhythm
GO:45821; positive regulation of glycolytic process
GO:35404; histone-serine phosphorylation
GO:42593; glucose homeostasis
GO:42149; cellular response to glucose starvation
GO:31669; cellular response to nutrient levels
GO:8610; lipid biosynthetic process
GO:1905691; lipid droplet disassembly
GO:16241; regulation of macroautophagy
GO:34599; cellular response to oxidative stress
GO:70507; regulation of microtubule cytoskeleton organization
GO:1904428; negative regulation of tubulin deacetylation
GO:71277; cellular response to calcium ion
GO:55089; fatty acid homeostasis
GO:16239; positive regulation of macroautophagy
GO:10468; regulation of gene expression
GO:14850; response to muscle activity
GO:62028; regulation of stress granule assembly
GO:71333; cellular response to glucose stimulus
GO:71380; cellular response to prostaglandin E stimulus
GO:71466; cellular response to xenobiotic stimulus
GO:1903829; positive regulation of cellular protein localization
GO:1990044; protein localization to lipid droplet
GO:2000758; positive regulation of peptidyl-lysine acetylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:43025; neuronal cell body
GO:30424; axon
GO:30425; dendrite
GO:31588; nucleotide-activated protein kinase complex
GO:10494; cytoplasmic stress granule
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4679; AMP-activated protein kinase activity
GO:3682; chromatin binding
GO:35174; histone serine kinase activity
GO:47322; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:50405; [acetyl-CoA carboxylase] kinase activity
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Homologs of PRKAA2 in Model Organisms

No homologs found

External links

OMIM
600497
Ensembl
ENSG00000162409
Entrez Gene
5563
UniGene
437039
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKAA2
GeneCards
PRKAA2