Cell Senescence Entries for PRKCD

Cell Types
Lung fibroblast
Cell Lines
TIG-1
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Katakura et al. (2009) Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells. J Biochem 146(1)87-93 (PubMed)

PRKCD Gene Information

HGNC symbol
PRKCD 
Aliases
 
Common name
protein kinase C delta 
Entrez Id
5580
Description
The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017].

PRKCD Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:18108; peptidyl-tyrosine phosphorylation
GO:2000303; regulation of ceramide biosynthetic process
GO:80090; regulation of primary metabolic process
GO:18105; peptidyl-serine phosphorylation
GO:42742; defense response to bacterium
GO:35556; intracellular signal transduction
GO:50821; protein stabilization
GO:42307; positive regulation of protein import into nucleus
GO:7165; signal transduction
GO:34351; negative regulation of glial cell apoptotic process
GO:60326; cell chemotaxis
GO:32091; negative regulation of protein binding
GO:18107; peptidyl-threonine phosphorylation
GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:34644; cellular response to UV
GO:50728; negative regulation of inflammatory response
GO:16572; histone phosphorylation
GO:30837; negative regulation of actin filament polymerization
GO:32930; positive regulation of superoxide anion generation
GO:70301; cellular response to hydrogen peroxide
GO:10469; regulation of signaling receptor activity
GO:2001022; positive regulation of response to DNA damage stimulus
GO:90398; cellular senescence
GO:43407; negative regulation of MAP kinase activity
GO:46627; negative regulation of insulin receptor signaling pathway
GO:23021; termination of signal transduction
GO:35307; positive regulation of protein dephosphorylation
GO:42119; neutrophil activation
GO:51490; negative regulation of filopodium assembly
GO:90331; negative regulation of platelet aggregation
GO:43488; regulation of mRNA stability
GO:50732; negative regulation of peptidyl-tyrosine phosphorylation
GO:32079; positive regulation of endodeoxyribonuclease activity
GO:8631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:32147; activation of protein kinase activity
GO:32956; regulation of actin cytoskeleton organization
GO:71447; cellular response to hydroperoxide
GO:1900163; positive regulation of phospholipid scramblase activity
GO:1904385; cellular response to angiotensin
GO:2000304; positive regulation of ceramide biosynthetic process
GO:2000753; positive regulation of glucosylceramide catabolic process
GO:2000755; positive regulation of sphingomyelin catabolic process
GO:16064; immunoglobulin mediated immune response
GO:42100; B cell proliferation
GO:2001235; positive regulation of apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:12505; endomembrane system
GO:48471; perinuclear region of cytoplasm
GO:5576; extracellular region
GO:5654; nucleoplasm
GO:70062; extracellular exosome
GO:35578; azurophil granule lumen
GO:36019; endolysosome
GO:5911; cell-cell junction
GO:16363; nuclear matrix
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:4697; protein kinase C activity
GO:4698; calcium-dependent protein kinase C activity
GO:19899; enzyme binding
GO:19901; protein kinase binding
GO:8047; enzyme activator activity
GO:19900; kinase binding
GO:43560; insulin receptor substrate binding
GO:4699; calcium-independent protein kinase C activity
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Homologs of PRKCD in Model Organisms

Danio rerio
BX005175.1
Mus musculus
Prkcd
Rattus norvegicus
Prkcd
Schizosaccharomyces pombe
pck1

In other databases

GenAge human genes
  • This gene is present as PRKCD

External links

OMIM
176977
Ensembl
ENSG00000163932
Entrez Gene
5580
UniGene
155342
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKCD
GeneCards
PRKCD