Cell Senescence Entries for PRKD1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wang et al. (2014) Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation. Proc Natl Acad Sci U S A 111(21)7683-8 (PubMed)

PRKD1 Gene Information

HGNC symbol
PRKD1 
Aliases
PKC-mu; PKCM; PKD; PRKCM 
Common name
protein kinase D1 
Entrez Id
5587
Description
The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017].

PRKD1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:30154; cell differentiation
GO:2376; immune system process
GO:45087; innate immune response
GO:7399; nervous system development
GO:18105; peptidyl-serine phosphorylation
GO:6954; inflammatory response
GO:1525; angiogenesis
GO:46777; protein autophosphorylation
GO:7265; Ras protein signal transduction
GO:7030; Golgi organization
GO:31647; regulation of protein stability
GO:34599; cellular response to oxidative stress
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1938; positive regulation of endothelial cell proliferation
GO:7165; signal transduction
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:45766; positive regulation of angiogenesis
GO:30148; sphingolipid biosynthetic process
GO:10595; positive regulation of endothelial cell migration
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:18107; peptidyl-threonine phosphorylation
GO:7229; integrin-mediated signaling pathway
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:10976; positive regulation of neuron projection development
GO:60548; negative regulation of cell death
GO:48193; Golgi vesicle transport
GO:35556; intracellular signal transduction
GO:89700; protein kinase D signaling
GO:45669; positive regulation of osteoblast differentiation
GO:38033; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:2001028; positive regulation of endothelial cell chemotaxis
GO:32793; positive regulation of CREB transcription factor activity
GO:1901727; positive regulation of histone deacetylase activity
GO:45806; negative regulation of endocytosis
GO:10837; regulation of keratinocyte proliferation
GO:10508; positive regulation of autophagy
GO:71447; cellular response to hydroperoxide
GO:34198; cellular response to amino acid starvation
GO:42307; positive regulation of protein import into nucleus
GO:43552; positive regulation of phosphatidylinositol 3-kinase activity
GO:50829; defense response to Gram-negative bacterium
GO:51279; regulation of release of sequestered calcium ion into cytosol
GO:2001044; regulation of integrin-mediated signaling pathway
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5829; cytosol
GO:5886; plasma membrane
GO:5802; trans-Golgi network
GO:421; autophagosome membrane
GO:5634; nucleus
GO:5911; cell-cell junction
GO:5938; cell cortex
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4697; protein kinase C activity
GO:4698; calcium-dependent protein kinase C activity
GO:42802; identical protein binding
Hide GO terms

Homologs of PRKD1 in Model Organisms

Danio rerio
prkd1
Mus musculus
Prkd1
Rattus norvegicus
Prkd1

External links

OMIM
605435
Ensembl
ENSG00000184304
Entrez Gene
5587
UniGene
508999
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKD1
GeneCards
PRKD1