Cell Senescence Entries for PRKD2

Cell Types
Glioblastoma, Glioma
Cell Lines
A172, GBM2, Gli25, GM133, T98G, U251, U87MG
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Bernhart et al. (2015) Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways. Neuro Oncol 16(7)933-45 (PubMed)

PRKD2 Gene Information

HGNC symbol
PRKD2 
Aliases
DKFZP586E0820; HSPC187; PKD2 
Common name
protein kinase D2 
Entrez Id
25865
Description
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

PRKD2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7155; cell adhesion
GO:2376; immune system process
GO:18105; peptidyl-serine phosphorylation
GO:2250; adaptive immune response
GO:1525; angiogenesis
GO:50862; positive regulation of T cell receptor signaling pathway
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1938; positive regulation of endothelial cell proliferation
GO:32757; positive regulation of interleukin-8 production
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:45785; positive regulation of cell adhesion
GO:45766; positive regulation of angiogenesis
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:30148; sphingolipid biosynthetic process
GO:10595; positive regulation of endothelial cell migration
GO:18107; peptidyl-threonine phosphorylation
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:1902533; positive regulation of intracellular signal transduction
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:32743; positive regulation of interleukin-2 production
GO:8219; cell death
GO:35556; intracellular signal transduction
GO:89700; protein kinase D signaling
GO:2000573; positive regulation of DNA biosynthetic process
GO:46777; protein autophosphorylation
GO:38033; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:2001028; positive regulation of endothelial cell chemotaxis
GO:30949; positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:32793; positive regulation of CREB transcription factor activity
GO:1901727; positive regulation of histone deacetylase activity
GO:61154; endothelial tube morphogenesis
GO:50852; T cell receptor signaling pathway
GO:45743; positive regulation of fibroblast growth factor receptor signaling pathway
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4697; protein kinase C activity
GO:4698; calcium-dependent protein kinase C activity
GO:5080; protein kinase C binding
Hide GO terms

Homologs of PRKD2 in Model Organisms

Caenorhabditis elegans
dkf-2
Drosophila melanogaster
PKD
Mus musculus
Prkd2
Rattus norvegicus
Prkd2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as dkf-2

External links

OMIM
607074
Ensembl
ENSG00000105287
Entrez Gene
25865
UniGene
466987
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKD2
GeneCards
PRKD2