Cell Senescence Entries for PRKDC

Cell Types
Lung cancer
Cell Lines
H460
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Azad et al. (2012) Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells. Mol Cancer Res 9(12)1696-707 (PubMed)

PRKDC Gene Information

HGNC symbol
PRKDC 
Aliases
DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1; HYRC; HYRC1; p350; p460; XRCC7 
Common name
protein kinase, DNA-activated, catalytic subunit 
Entrez Id
5591
Description
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].

PRKDC Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6303; double-strand break repair via nonhomologous end joining
GO:6310; DNA recombination
GO:2376; immune system process
GO:45087; innate immune response
GO:48511; rhythmic process
GO:6468; protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:1902036; regulation of hematopoietic stem cell differentiation
GO:42254; ribosome biogenesis
GO:6302; double-strand break repair
GO:2001034; positive regulation of double-strand break repair via nonhomologous end joining
GO:1933; negative regulation of protein phosphorylation
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6464; cellular protein modification process
GO:45727; positive regulation of translation
GO:42752; regulation of circadian rhythm
GO:18107; peptidyl-threonine phosphorylation
GO:2218; activation of innate immune response
GO:32869; cellular response to insulin stimulus
GO:723; telomere maintenance
GO:45648; positive regulation of erythrocyte differentiation
GO:43066; negative regulation of apoptotic process
GO:45621; positive regulation of lymphocyte differentiation
GO:48660; regulation of smooth muscle cell proliferation
GO:34462; small-subunit processome assembly
GO:33152; immunoglobulin V(D)J recombination
GO:31571; mitotic G1 DNA damage checkpoint signaling
GO:460; maturation of 5.8S rRNA
GO:1756; somitogenesis
GO:2326; B cell lineage commitment
GO:2328; pro-B cell differentiation
GO:2360; T cell lineage commitment
GO:7420; brain development
GO:7507; heart development
GO:10212; response to ionizing radiation
GO:10332; response to gamma radiation
GO:16233; telomere capping
GO:30098; lymphocyte differentiation
GO:31648; protein destabilization
GO:33077; T cell differentiation in thymus
GO:33151; V(D)J recombination
GO:33153; T cell receptor V(D)J recombination
GO:35234; ectopic germ cell programmed cell death
GO:43065; positive regulation of apoptotic process
GO:50678; regulation of epithelial cell proliferation
GO:97681; double-strand break repair via alternative nonhomologous end joining
GO:1905221; positive regulation of platelet formation
GO:44238; primary metabolic process
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:32991; protein-containing complex
GO:32993; protein-DNA complex
GO:32040; small-subunit processome
GO:70418; DNA-dependent protein kinase complex
GO:70419; nonhomologous end joining complex
GO:5958; DNA-dependent protein kinase-DNA ligase 4 complex
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3677; DNA binding
GO:19904; protein domain specific binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:4672; protein kinase activity
GO:34511; U3 snoRNA binding
GO:3690; double-stranded DNA binding
GO:4677; DNA-dependent protein kinase activity
GO:19899; enzyme binding
Hide GO terms

Homologs of PRKDC in Model Organisms

Danio rerio
wu:fa96e12
Mus musculus
Prkdc
Rattus norvegicus
Prkdc

In other databases

GenAge human genes
  • This gene is present as PRKDC
LongevityMap
  • This gene is present as PRKDC

External links

OMIM
600899
Ensembl
ENSG00000253729
Entrez Gene
5591
UniGene
491682
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKDC
GeneCards
PRKDC