Cell Senescence Entries for PRKN

Cell Types
Bronchial epithelial
Cell Lines
BEAS-2B
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ito et al. (2016) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy 11(3)547-59 (PubMed)

PRKN Gene Information

HGNC symbol
PRKN 
Aliases
AR-JP; PARK2; parkin; PDJ 
Common name
parkin RBR E3 ubiquitin protein ligase 
Entrez Id
5071
Description
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008].

PRKN Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:6914; autophagy
GO:50896; response to stimulus
GO:51865; protein autoubiquitination
GO:85020; protein K6-linked ubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:6464; cellular protein modification process
GO:70936; protein K48-linked ubiquitination
GO:31648; protein destabilization
GO:50821; protein stabilization
GO:422; autophagy of mitochondrion
GO:42981; regulation of apoptotic process
GO:423; mitophagy
GO:31396; regulation of protein ubiquitination
GO:70534; protein K63-linked ubiquitination
GO:1903214; regulation of protein targeting to mitochondrion
GO:7417; central nervous system development
GO:10821; regulation of mitochondrion organization
GO:7005; mitochondrion organization
GO:90141; positive regulation of mitochondrial fission
GO:10506; regulation of autophagy
GO:16579; protein deubiquitination
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:70979; protein K11-linked ubiquitination
GO:1933; negative regulation of protein phosphorylation
GO:9966; regulation of signal transduction
GO:10629; negative regulation of gene expression
GO:45944; positive regulation of transcription by RNA polymerase II
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:1990000; amyloid fibril formation
GO:34976; response to endoplasmic reticulum stress
GO:44257; cellular protein catabolic process
GO:1901215; negative regulation of neuron death
GO:1902236; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:33132; negative regulation of glucokinase activity
GO:46676; negative regulation of insulin secretion
GO:122; negative regulation of transcription by RNA polymerase II
GO:266; mitochondrial fission
GO:1963; synaptic transmission, dopaminergic
GO:1964; startle response
GO:6513; protein monoubiquitination
GO:6979; response to oxidative stress
GO:7612; learning
GO:7626; locomotory behavior
GO:8344; adult locomotory behavior
GO:10498; proteasomal protein catabolic process
GO:10628; positive regulation of gene expression
GO:10636; positive regulation of mitochondrial fusion
GO:10637; negative regulation of mitochondrial fusion
GO:10906; regulation of glucose metabolic process
GO:10994; free ubiquitin chain polymerization
GO:14059; regulation of dopamine secretion
GO:16236; macroautophagy
GO:19538; protein metabolic process
GO:31647; regulation of protein stability
GO:32092; positive regulation of protein binding
GO:32232; negative regulation of actin filament bundle assembly
GO:32368; regulation of lipid transport
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:34620; cellular response to unfolded protein
GO:35249; synaptic transmission, glutamatergic
GO:35519; protein K29-linked ubiquitination
GO:36503; ERAD pathway
GO:42053; regulation of dopamine metabolic process
GO:42415; norepinephrine metabolic process
GO:42417; dopamine metabolic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:43388; positive regulation of DNA binding
GO:43524; negative regulation of neuron apoptotic process
GO:44314; protein K27-linked ubiquitination
GO:44828; negative regulation by host of viral genome replication
GO:45732; positive regulation of protein catabolic process
GO:46329; negative regulation of JNK cascade
GO:46928; regulation of neurotransmitter secretion
GO:50804; modulation of chemical synaptic transmission
GO:51582; positive regulation of neurotransmitter uptake
GO:51583; dopamine uptake involved in synaptic transmission
GO:51881; regulation of mitochondrial membrane potential
GO:55069; zinc ion homeostasis
GO:60548; negative regulation of cell death
GO:60828; regulation of canonical Wnt signaling pathway
GO:61734; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:70050; neuron cellular homeostasis
GO:70585; protein localization to mitochondrion
GO:70842; aggresome assembly
GO:71287; cellular response to manganese ion
GO:90201; negative regulation of release of cytochrome c from mitochondria
GO:97237; cellular response to toxic substance
GO:98779; positive regulation of mitophagy in response to mitochondrial depolarization
GO:99074; mitochondrion to lysosome transport
GO:1900407; regulation of cellular response to oxidative stress
GO:1901800; positive regulation of proteasomal protein catabolic process
GO:1902254; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902283; negative regulation of primary amine oxidase activity
GO:1902530; positive regulation of protein linear polyubiquitination
GO:1902803; regulation of synaptic vesicle transport
GO:1903202; negative regulation of oxidative stress-induced cell death
GO:1903265; positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903351; cellular response to dopamine
GO:1903377; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903382; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542; negative regulation of exosomal secretion
GO:1903599; positive regulation of autophagy of mitochondrion
GO:1903861; positive regulation of dendrite extension
GO:1904049; negative regulation of spontaneous neurotransmitter secretion
GO:1905281; positive regulation of retrograde transport, endosome to Golgi
GO:1905366; negative regulation of intralumenal vesicle formation
GO:1905477; positive regulation of protein localization to membrane
GO:2000377; regulation of reactive oxygen species metabolic process
GO:2000378; negative regulation of reactive oxygen species metabolic process
GO:44248; cellular catabolic process
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16607; nuclear speck
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:5739; mitochondrion
GO:98793; presynapse
GO:5741; mitochondrial outer membrane
GO:30054; cell junction
GO:42995; cell projection
GO:45202; synapse
GO:43005; neuron projection
GO:48471; perinuclear region of cytoplasm
GO:14069; postsynaptic density
GO:151; ubiquitin ligase complex
GO:99073; mitochondrion-derived vesicle
GO:16235; aggresome
GO:32991; protein-containing complex
GO:97413; Lewy body
GO:1990452; Parkin-FBXW7-Cul1 ubiquitin ligase complex
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:31625; ubiquitin protein ligase binding
GO:4842; ubiquitin-protein transferase activity
GO:61630; ubiquitin protein ligase activity
GO:43130; ubiquitin binding
GO:42802; identical protein binding
GO:19901; protein kinase binding
GO:51087; chaperone binding
GO:30544; Hsp70 protein binding
GO:31072; heat shock protein binding
GO:19900; kinase binding
GO:31624; ubiquitin conjugating enzyme binding
GO:30165; PDZ domain binding
GO:8013; beta-catenin binding
GO:1664; G protein-coupled receptor binding
GO:3714; transcription corepressor activity
GO:3779; actin binding
GO:8270; zinc ion binding
GO:15631; tubulin binding
GO:17124; SH3 domain binding
GO:19899; enzyme binding
GO:42826; histone deacetylase binding
GO:43274; phospholipase binding
GO:44877; protein-containing complex binding
GO:97602; cullin family protein binding
GO:1990381; ubiquitin-specific protease binding
GO:1990444; F-box domain binding
GO:16874; ligase activity
Hide GO terms

Homologs of PRKN in Model Organisms

Caenorhabditis elegans
pdr-1
Drosophila melanogaster
park
Mus musculus
Park2
Rattus norvegicus
Park2

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as park
LongevityMap
  • This gene is present as PRKN

External links

OMIM
602544
Ensembl
ENSG00000185345
Entrez Gene
5071
UniGene
132954
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRKN
GeneCards
PRKN