Cell Senescence Entries for PRMT1

Cell Types
Neuroblastoma
Cell Lines
SK-N-SH
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2020) Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells. Sci Rep 9(1)1771 (PubMed)

PRMT1 Gene Information

HGNC symbol
PRMT1 
Aliases
ANM1; HCP1; HRMT1L2 
Common name
protein arginine methyltransferase 1 
Entrez Id
3276
Description
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011].

PRMT1 Ontologies

Gene Ontology
Process: GO:32259; methylation
GO:6325; chromatin organization
GO:18216; peptidyl-arginine methylation
GO:35246; peptidyl-arginine N-methylation
GO:16571; histone methylation
GO:8380; RNA splicing
GO:6479; protein methylation
GO:35247; peptidyl-arginine omega-N-methylation
GO:8284; positive regulation of cell population proliferation
GO:51260; protein homooligomerization
GO:19919; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:7166; cell surface receptor signaling pathway
GO:46329; negative regulation of JNK cascade
GO:31175; neuron projection development
GO:43985; histone H4-R3 methylation
GO:46985; positive regulation of hemoglobin biosynthetic process
GO:45652; regulation of megakaryocyte differentiation
GO:45653; negative regulation of megakaryocyte differentiation
GO:19082; viral protein processing
GO:45648; positive regulation of erythrocyte differentiation
GO:48738; cardiac muscle tissue development
GO:1900745; positive regulation of p38MAPK cascade
GO:1701; in utero embryonic development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:34709; methylosome
Function: GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:16274; protein-arginine N-methyltransferase activity
GO:8170; N-methyltransferase activity
GO:8757; S-adenosylmethionine-dependent methyltransferase activity
GO:3723; RNA binding
GO:42802; identical protein binding
GO:5515; protein binding
GO:35241; protein-arginine omega-N monomethyltransferase activity
GO:44020; histone methyltransferase activity (H4-R3 specific)
GO:19899; enzyme binding
GO:42054; histone methyltransferase activity
GO:35242; protein-arginine omega-N asymmetric methyltransferase activity
GO:8327; methyl-CpG binding
GO:48273; mitogen-activated protein kinase p38 binding
GO:1904047; S-adenosyl-L-methionine binding
GO:8276; protein methyltransferase activity
Hide GO terms

Homologs of PRMT1 in Model Organisms

Danio rerio
prmt1
Mus musculus
Prmt1
Rattus norvegicus
Prmt1

External links

OMIM
602950
Ensembl
ENSG00000126457
Entrez Gene
3276
UniGene
20521
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRMT1
GeneCards
PRMT1