Cell Senescence Entries for PRMT6

Cell Types
Breast cancer, Breast epithelial
Cell Lines
MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Phalke et al. (2013) p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6. Nucleic Acids Res 40(19)9534-42 (PubMed)

PRMT6 Gene Information

HGNC symbol
PRMT6 
Aliases
FLJ10559; HRMT1L6 
Common name
protein arginine methyltransferase 6 
Entrez Id
55170
Description
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011].

PRMT6 Ontologies

Gene Ontology
Process: GO:32259; methylation
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:18216; peptidyl-arginine methylation
GO:43985; histone H4-R3 methylation
GO:16571; histone methylation
GO:6284; base-excision repair
GO:10821; regulation of mitochondrion organization
GO:31064; negative regulation of histone deacetylation
GO:34970; histone H3-R2 methylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:19919; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:35246; peptidyl-arginine N-methylation
GO:45652; regulation of megakaryocyte differentiation
GO:51572; negative regulation of histone H3-K4 methylation
GO:90398; cellular senescence
GO:1901796; regulation of signal transduction by p53 class mediator
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
Function: GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:5515; protein binding
GO:16274; protein-arginine N-methyltransferase activity
GO:35241; protein-arginine omega-N monomethyltransferase activity
GO:44020; histone methyltransferase activity (H4-R3 specific)
GO:42054; histone methyltransferase activity
GO:35242; protein-arginine omega-N asymmetric methyltransferase activity
GO:42393; histone binding
GO:8469; histone-arginine N-methyltransferase activity
GO:3682; chromatin binding
GO:70611; histone methyltransferase activity (H3-R2 specific)
GO:70612; histone methyltransferase activity (H2A-R3 specific)
GO:8170; N-methyltransferase activity
GO:8757; S-adenosylmethionine-dependent methyltransferase activity
Hide GO terms

Homologs of PRMT6 in Model Organisms

Danio rerio
prmt6
Mus musculus
Prmt6
Rattus norvegicus
LOC100911617

In other databases

CellAge gene expression
  • This gene is present as PRMT6

External links

OMIM
608274
Ensembl
ENSG00000198890
Entrez Gene
55170
UniGene
26006
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRMT6
GeneCards
PRMT6