The PROX1 gene and its putative association with human ageing

Cell Types

Liver cancer

Cell Lines

Hep G2, Hep3B, Mahlavu, SK-HEP-1

Cancer Cell?

Yes

Method

Overexpression

Type of senescence

Replicative

Senescence Effect

Induces

Primary Reference

Chang et al. (2013) The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype. Cancer Biol Ther 14(3)222-9 (PubMed)

HGNC symbol

PROX1

Aliases

Common name

prospero homeobox 1

Entrez Id

5629

Description

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:6357; regulation of transcription by RNA polymerase II
GO:8284; positive regulation of cell population proliferation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1938; positive regulation of endothelial cell proliferation
GO:122; negative regulation of transcription by RNA polymerase II
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:10595; positive regulation of endothelial cell migration
GO:42752; regulation of circadian rhythm
GO:21915; neural tube development
GO:8285; negative regulation of cell population proliferation
GO:55010; ventricular cardiac muscle tissue morphogenesis
GO:60412; ventricular septum morphogenesis
GO:30240; skeletal muscle thin filament assembly
GO:21707; cerebellar granule cell differentiation
GO:60042; retina morphogenesis in camera-type eye
GO:1822; kidney development
GO:30324; lung development
GO:1889; liver development
GO:45787; positive regulation of cell cycle
GO:55009; atrial cardiac muscle tissue morphogenesis
GO:60298; positive regulation of sarcomere organization
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:45071; negative regulation of viral genome replication
GO:7420; brain development
GO:60059; embryonic retina morphogenesis in camera-type eye
GO:10468; regulation of gene expression
GO:2088; lens development in camera-type eye
GO:48845; venous blood vessel morphogenesis
GO:60838; lymphatic endothelial cell fate commitment
GO:60836; lymphatic endothelial cell differentiation
GO:60214; endocardium formation
GO:1946; lymphangiogenesis
GO:21542; dentate gyrus development
GO:31016; pancreas development
GO:60414; aorta smooth muscle tissue morphogenesis
GO:1709; cell fate determination
GO:1945; lymph vessel development
GO:2089; lens morphogenesis in camera-type eye
GO:2194; hepatocyte cell migration
GO:7623; circadian rhythm
GO:21516; dorsal spinal cord development
GO:30910; olfactory placode formation
GO:31667; response to nutrient levels
GO:43049; otic placode formation
GO:45446; endothelial cell differentiation
GO:46619; lens placode formation involved in camera-type eye formation
GO:48839; inner ear development
GO:55005; ventricular cardiac myofibril assembly
GO:60421; positive regulation of heart growth
GO:61114; branching involved in pancreas morphogenesis
GO:70309; lens fiber cell morphogenesis
GO:70365; hepatocyte differentiation
GO:70858; negative regulation of bile acid biosynthetic process
GO:72574; hepatocyte proliferation
GO:90425; acinar cell differentiation
GO:97150; neuronal stem cell population maintenance
GO:1901978; positive regulation of cell cycle checkpoint
GO:2000179; positive regulation of neural precursor cell proliferation
GO:2000979; positive regulation of forebrain neuron differentiation

Cellular component:

GO:5654; nucleoplasm
GO:5829; cytosol
GO:5737; cytoplasm
GO:5634; nucleus
GO:785; chromatin

Function:

GO:5515; protein binding
GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:976; transcription cis-regulatory region binding
GO:3700; DNA-binding transcription factor activity
GO:16922; nuclear receptor binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:50692; DNA binding domain binding
GO:50693; LBD domain binding

Hide GO terms

Danio rerio

Mus musculus

Rattus norvegicus

OMIM

Ensembl

Entrez Gene