Cell Senescence Entries for PRPF19

Cell Types
Dermal fibroblast, Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Voglauer et al. (2006) SNEV overexpression extends the life span of human endothelial cells. Exp Cell Res 312(6)746-59 (PubMed)

PRPF19 Gene Information

HGNC symbol
PRPF19 
Aliases
hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4 
Common name
pre-mRNA processing factor 19 
Entrez Id
27339
Description
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008].

PRPF19 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:16567; protein ubiquitination
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:398; mRNA splicing, via spliceosome
GO:70534; protein K63-linked ubiquitination
GO:10498; proteasomal protein catabolic process
GO:6303; double-strand break repair via nonhomologous end joining
GO:77; DNA damage checkpoint signaling
GO:244; spliceosomal tri-snRNP complex assembly
GO:209; protein polyubiquitination
GO:34613; cellular protein localization
GO:245; spliceosomal complex assembly
GO:8610; lipid biosynthetic process
GO:45666; positive regulation of neuron differentiation
GO:48026; positive regulation of mRNA splicing, via spliceosome
GO:48711; positive regulation of astrocyte differentiation
Cellular component: GO:5634; nucleus
GO:5681; spliceosomal complex
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:16020; membrane
GO:5856; cytoskeleton
GO:5654; nucleoplasm
GO:5819; spindle
GO:71013; catalytic step 2 spliceosome
GO:5811; lipid droplet
GO:35861; site of double-strand break
GO:974; Prp19 complex
GO:5662; DNA replication factor A complex
GO:71007; U2-type catalytic step 2 spliceosome
GO:71006; U2-type catalytic step 1 spliceosome
Function: GO:16740; transferase activity
GO:4842; ubiquitin-protein transferase activity
GO:5515; protein binding
GO:61630; ubiquitin protein ligase activity
GO:42802; identical protein binding
GO:34450; ubiquitin-ubiquitin ligase activity
Hide GO terms

Homologs of PRPF19 in Model Organisms

Caenorhabditis elegans
T10F2.4
Danio rerio
prp19
Drosophila melanogaster
Prp19
Mus musculus
Prpf19
Rattus norvegicus
Prpf19
Saccharomyces cerevisiae
PRP19
Schizosaccharomyces pombe
cwf8

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Prp19

External links

OMIM
608330
Ensembl
ENSG00000110107
Entrez Gene
27339
UniGene
502705
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRPF19
GeneCards
PRPF19