Cell Senescence Entries for PSMB5

Cell Types
Multipotent bone marrow stromal
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Lu et al. (2014) Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression. Biochem Biophys Res Commun 443(4)1182-8 (PubMed)

PSMB5 Gene Information

HGNC symbol
PSMB5 
Aliases
MB1 
Common name
proteasome 20S subunit beta 5 
Entrez Id
5693
Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].

PSMB5 Ontologies

Gene Ontology
Process: GO:16579; protein deubiquitination
GO:43488; regulation of mRNA stability
GO:43687; post-translational protein modification
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:165; MAPK cascade
GO:2223; stimulatory C-type lectin receptor signaling pathway
GO:2479; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:6521; regulation of cellular amino acid metabolic process
GO:10972; negative regulation of G2/M transition of mitotic cell cycle
GO:31145; anaphase-promoting complex-dependent catabolic process
GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:36388; pre-replicative complex assembly
GO:38061; NIK/NF-kappaB signaling
GO:38095; Fc-epsilon receptor signaling pathway
GO:50852; T cell receptor signaling pathway
GO:51603; proteolysis involved in cellular protein catabolic process
GO:55085; transmembrane transport
GO:60071; Wnt signaling pathway, planar cell polarity pathway
GO:61418; regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:70498; interleukin-1-mediated signaling pathway
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:1902036; regulation of hematopoietic stem cell differentiation
GO:6508; proteolysis
GO:10498; proteasomal protein catabolic process
GO:6979; response to oxidative stress
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:502; proteasome complex
GO:5839; proteasome core complex
GO:5654; nucleoplasm
GO:5813; centrosome
GO:70062; extracellular exosome
GO:19774; proteasome core complex, beta-subunit complex
Function: GO:4298; threonine-type endopeptidase activity
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4175; endopeptidase activity
Hide GO terms

Homologs of PSMB5 in Model Organisms

Danio rerio
psmb5
Mus musculus
Psmb5
Rattus norvegicus
Psmb5

External links

OMIM
600306
Ensembl
ENSG00000100804
Entrez Gene
5693
UniGene
422990
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PSMB5
GeneCards
PSMB5