The PTEN gene and its putative association with human ageing

Cell Types

Breast cancer

Cell Lines

MCF-7

Cancer Cell?

Yes

Method

Knockdown

Type of senescence

Unclear

Senescence Effect

Inhibits

Primary Reference

Jung et al. (2019) mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53. Oncogene 38(10)1639-1650 (PubMed)

HGNC symbol

PTEN

Aliases

BZS; MHAM; MMAC1; PTEN1; TEP1

Common name

phosphatase and tensin homolog

Entrez Id

5728

Description

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015].

Gene Ontology

Process:

GO:16311; dephosphorylation
GO:6629; lipid metabolic process
GO:35335; peptidyl-tyrosine dephosphorylation
GO:7399; nervous system development
GO:6470; protein dephosphorylation
GO:46855; inositol phosphate dephosphorylation
GO:8285; negative regulation of cell population proliferation
GO:46856; phosphatidylinositol dephosphorylation
GO:6915; apoptotic process
GO:7507; heart development
GO:16477; cell migration
GO:8284; positive regulation of cell population proliferation
GO:1525; angiogenesis
GO:1933; negative regulation of protein phosphorylation
GO:2902; regulation of B cell apoptotic process
GO:7270; neuron-neuron synaptic transmission
GO:7416; synapse assembly
GO:7417; central nervous system development
GO:7611; learning or memory
GO:7626; locomotory behavior
GO:10975; regulation of neuron projection development
GO:21542; dentate gyrus development
GO:21955; central nervous system neuron axonogenesis
GO:30534; adult behavior
GO:31642; negative regulation of myelination
GO:32228; regulation of synaptic transmission, GABAergic
GO:32286; central nervous system myelin maintenance
GO:32535; regulation of cellular component size
GO:33032; regulation of myeloid cell apoptotic process
GO:33555; multicellular organismal response to stress
GO:35176; social behavior
GO:36294; cellular response to decreased oxygen levels
GO:42711; maternal behavior
GO:43066; negative regulation of apoptotic process
GO:43491; protein kinase B signaling
GO:43542; endothelial cell migration
GO:45475; locomotor rhythm
GO:45792; negative regulation of cell size
GO:46621; negative regulation of organ growth
GO:48679; regulation of axon regeneration
GO:48681; negative regulation of axon regeneration
GO:48738; cardiac muscle tissue development
GO:48853; forebrain morphogenesis
GO:48854; brain morphogenesis
GO:50680; negative regulation of epithelial cell proliferation
GO:50771; negative regulation of axonogenesis
GO:51726; regulation of cell cycle
GO:51898; negative regulation of protein kinase B signaling
GO:60024; rhythmic synaptic transmission
GO:60044; negative regulation of cardiac muscle cell proliferation
GO:60074; synapse maturation
GO:60134; prepulse inhibition
GO:60179; male mating behavior
GO:60291; long-term synaptic potentiation
GO:60341; regulation of cellular localization
GO:60736; prostate gland growth
GO:60997; dendritic spine morphogenesis
GO:61002; negative regulation of dendritic spine morphogenesis
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:71456; cellular response to hypoxia
GO:90071; negative regulation of ribosome biogenesis
GO:90344; negative regulation of cell aging
GO:90394; negative regulation of excitatory postsynaptic potential
GO:97105; presynaptic membrane assembly
GO:97107; postsynaptic density assembly
GO:1904668; positive regulation of ubiquitin protein ligase activity
GO:2000463; positive regulation of excitatory postsynaptic potential
GO:2000808; negative regulation of synaptic vesicle clustering
GO:2001235; positive regulation of apoptotic signaling pathway
GO:31647; regulation of protein stability
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:1902807; negative regulation of cell cycle G1/S phase transition
GO:14065; phosphatidylinositol 3-kinase signaling
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:6661; phosphatidylinositol biosynthetic process
GO:50821; protein stabilization
GO:60070; canonical Wnt signaling pathway
GO:51895; negative regulation of focal adhesion assembly
GO:48870; cell motility
GO:10719; negative regulation of epithelial to mesenchymal transition
GO:30336; negative regulation of cell migration
GO:2000060; positive regulation of ubiquitin-dependent protein catabolic process
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:10977; negative regulation of neuron projection development
GO:1904706; negative regulation of vascular associated smooth muscle cell proliferation
GO:51896; regulation of protein kinase B signaling
GO:33137; negative regulation of peptidyl-serine phosphorylation
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:1903984; positive regulation of TRAIL-activated apoptotic signaling pathway
GO:14067; negative regulation of phosphatidylinositol 3-kinase signaling
GO:51548; negative regulation of keratinocyte migration
GO:71257; cellular response to electrical stimulus
GO:1903690; negative regulation of wound healing, spreading of epidermal cells

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:45202; synapse
GO:16605; PML body
GO:5886; plasma membrane
GO:5576; extracellular region
GO:16324; apical plasma membrane
GO:42995; cell projection
GO:35749; myelin sheath adaxonal region
GO:43005; neuron projection
GO:43220; Schmidt-Lanterman incisure
GO:9898; cytoplasmic side of plasma membrane

Function:

GO:16791; phosphatase activity
GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:4438; phosphatidylinositol-3-phosphatase activity
GO:4725; protein tyrosine phosphatase activity
GO:16314; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:51717; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:51800; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:5515; protein binding
GO:8289; lipid binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:19901; protein kinase binding
GO:30165; PDZ domain binding
GO:10997; anaphase-promoting complex binding
GO:1990381; ubiquitin-specific protease binding

Hide GO terms

Danio rerio

ptena

Drosophila melanogaster

Pten

Mus musculus

Pten

Rattus norvegicus

Pten

GenAge model organism genes