Cell Senescence Entries for PTPN1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Primary Reference
Yang et al. (2014) Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence. Mol Cell 55(5)782-90 (PubMed)

PTPN1 Gene Information

HGNC symbol
PTPN1 
Aliases
PTP1B 
Common name
protein tyrosine phosphatase non-receptor type 1 
Entrez Id
5770
Description
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].

PTPN1 Ontologies

Gene Ontology
Process: GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
GO:30100; regulation of endocytosis
GO:8286; insulin receptor signaling pathway
GO:30948; negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:34976; response to endoplasmic reticulum stress
GO:35791; platelet-derived growth factor receptor-beta signaling pathway
GO:36498; IRE1-mediated unfolded protein response
GO:43507; positive regulation of JUN kinase activity
GO:46626; regulation of insulin receptor signaling pathway
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:1902236; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903898; negative regulation of PERK-mediated unfolded protein response
GO:1990264; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO:9966; regulation of signal transduction
GO:31532; actin cytoskeleton reorganization
GO:1903896; positive regulation of IRE1-mediated unfolded protein response
GO:34620; cellular response to unfolded protein
GO:30968; endoplasmic reticulum unfolded protein response
GO:43407; negative regulation of MAP kinase activity
GO:46627; negative regulation of insulin receptor signaling pathway
GO:60397; growth hormone receptor signaling pathway via JAK-STAT
GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway
GO:9968; negative regulation of signal transduction
GO:33157; regulation of intracellular protein transport
GO:60338; regulation of type I interferon-mediated signaling pathway
GO:61098; positive regulation of protein tyrosine kinase activity
GO:2000646; positive regulation of receptor catabolic process
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:5769; early endosome
GO:5829; cytosol
GO:5737; cytoplasm
GO:5759; mitochondrial matrix
GO:30061; mitochondrial crista
GO:31410; cytoplasmic vesicle
GO:97443; sorting endosome
GO:32991; protein-containing complex
GO:98554; cytoplasmic side of endoplasmic reticulum membrane
Function: GO:16787; hydrolase activity
GO:4721; phosphoprotein phosphatase activity
GO:4725; protein tyrosine phosphatase activity
GO:16791; phosphatase activity
GO:3723; RNA binding
GO:8270; zinc ion binding
GO:5515; protein binding
GO:19899; enzyme binding
GO:45296; cadherin binding
GO:19901; protein kinase binding
GO:5158; insulin receptor binding
GO:51721; protein phosphatase 2A binding
GO:30971; receptor tyrosine kinase binding
GO:46875; ephrin receptor binding
Hide GO terms

Homologs of PTPN1 in Model Organisms

Danio rerio
ptpn1
Mus musculus
Ptpn1
Rattus norvegicus
Ptpn1

In other databases

GenAge human genes
  • This gene is present as PTPN1

External links

OMIM
176885
Ensembl
ENSG00000196396
Entrez Gene
5770
UniGene
417549
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PTPN1
GeneCards
PTPN1