Cell Senescence Entries for PTTG1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, IMR-90, WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Hsu et al. (2010) Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts. J Biol Chem 285(29)22630-8 (PubMed)

PTTG1 Gene Information

HGNC symbol
PTTG1 
Aliases
EAP1; HPTTG; PTTG; securin; TUTR1 
Common name
PTTG1 regulator of sister chromatid separation, securin 
Entrez Id
9232
Description
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].

PTTG1 Ontologies

Gene Ontology
Process: GO:10951; negative regulation of endopeptidase activity
GO:7049; cell cycle
GO:51301; cell division
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:51276; chromosome organization
GO:7059; chromosome segregation
GO:45143; homologous chromosome segregation
GO:7283; spermatogenesis
GO:2000816; negative regulation of mitotic sister chromatid separation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
Function: GO:17124; SH3 domain binding
GO:5515; protein binding
GO:4869; cysteine-type endopeptidase inhibitor activity
Hide GO terms

Homologs of PTTG1 in Model Organisms

No homologs found

In other databases

CellAge gene expression
  • This gene is present as PTTG1

External links

OMIM
604147
Ensembl
ENSG00000164611
Entrez Gene
9232
UniGene
350966
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PTTG1
GeneCards
PTTG1