Cell Senescence Entries for PYGL

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Favaro et al. (2013) Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells. Cell Metab 16(6)751-64 (PubMed)

PYGL Gene Information

HGNC symbol
PYGL 
Aliases
GSD6 
Common name
glycogen phosphorylase L 
Entrez Id
5836
Description
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011].

PYGL Ontologies

Gene Ontology
Process: GO:5975; carbohydrate metabolic process
GO:5977; glycogen metabolic process
GO:8152; metabolic process
GO:42593; glucose homeostasis
GO:5980; glycogen catabolic process
GO:6015; 5-phosphoribose 1-diphosphate biosynthetic process
GO:9617; response to bacterium
GO:70266; necroptotic process
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
Function: GO:16740; transferase activity
GO:16757; glycosyltransferase activity
GO:3824; catalytic activity
GO:30170; pyridoxal phosphate binding
GO:4645; 1,4-alpha-oligoglucan phosphorylase activity
GO:8184; glycogen phosphorylase activity
GO:102250; linear malto-oligosaccharide phosphorylase activity
GO:102499; SHG alpha-glucan phosphorylase activity
GO:166; nucleotide binding
GO:5524; ATP binding
GO:42802; identical protein binding
GO:5515; protein binding
GO:2060; purine nucleobase binding
GO:32052; bile acid binding
GO:5536; glucose binding
GO:16208; AMP binding
GO:19842; vitamin binding
GO:30246; carbohydrate binding
Hide GO terms

Homologs of PYGL in Model Organisms

Caenorhabditis elegans
CELE_T22F3.3
Drosophila melanogaster
GlyP
Mus musculus
Pygl
Rattus norvegicus
Pygl

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as GlyP

External links

OMIM
613741
Ensembl
ENSG00000100504
Entrez Gene
5836
UniGene
282417
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PYGL
GeneCards
PYGL