Cell Senescence Entries for RACGAP1

Cell Types
Breast cancer
Cell Lines
HCC1937, SUM149
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Lawson et al. (2017) Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers. Cancer Res 76(13)3826-37 (PubMed)

RACGAP1 Gene Information

HGNC symbol
RACGAP1 
Aliases
MgcRacGAP 
Common name
Rac GTPase activating protein 1 
Entrez Id
29127
Description
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016].

RACGAP1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:7049; cell cycle
GO:6811; ion transport
GO:50790; regulation of catalytic activity
GO:51301; cell division
GO:30154; cell differentiation
GO:51056; regulation of small GTPase mediated signal transduction
GO:7283; spermatogenesis
GO:7405; neuroblast proliferation
GO:281; mitotic cytokinesis
GO:32467; positive regulation of cytokinesis
GO:51256; mitotic spindle midzone assembly
GO:45995; regulation of embryonic development
GO:51988; regulation of attachment of spindle microtubules to kinetochore
GO:8272; sulfate transport
GO:915; actomyosin contractile ring assembly
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:31410; cytoplasmic vesicle
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5874; microtubule
GO:5819; spindle
GO:1669; acrosomal vesicle
GO:30496; midbody
GO:32154; cleavage furrow
GO:5829; cytosol
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:70062; extracellular exosome
GO:51233; spindle midzone
GO:72686; mitotic spindle
GO:90543; Flemming body
GO:97149; centralspindlin complex
Function: GO:46872; metal ion binding
GO:5096; GTPase activator activity
GO:5515; protein binding
GO:8289; lipid binding
GO:8017; microtubule binding
GO:19901; protein kinase binding
GO:43014; alpha-tubulin binding
GO:5547; phosphatidylinositol-3,4,5-trisphosphate binding
GO:43015; gamma-tubulin binding
GO:48487; beta-tubulin binding
Hide GO terms

Homologs of RACGAP1 in Model Organisms

Caenorhabditis elegans
cyk-4
Danio rerio
racgap1
Drosophila melanogaster
tum
Mus musculus
Racgap1
Rattus norvegicus
Racgap1

In other databases

CellAge gene expression

External links

OMIM
604980
Ensembl
ENSG00000161800
Entrez Gene
29127
UniGene
505469
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RACGAP1
GeneCards
RACGAP1