Cell Senescence Entries for RAD21

Cell Types
Breast cancer
Cell Lines
MDA-MB-231
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Zhu et al. (2016) Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation. J Cell Biochem 117(6)1359-69 (PubMed)

RAD21 Gene Information

HGNC symbol
RAD21 
Aliases
hHR21; KIAA0078; SCC1 
Common name
RAD21 cohesin complex component 
Entrez Id
5885
Description
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008].

RAD21 Ontologies

Gene Ontology
Process: GO:7059; chromosome segregation
GO:7062; sister chromatid cohesion
GO:7049; cell cycle
GO:6915; apoptotic process
GO:51301; cell division
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:10972; negative regulation of G2/M transition of mitotic cell cycle
GO:45841; negative regulation of mitotic metaphase/anaphase transition
GO:7130; synaptonemal complex assembly
GO:6357; regulation of transcription by RNA polymerase II
GO:6310; DNA recombination
GO:7131; reciprocal meiotic recombination
GO:6302; double-strand break repair
GO:7064; mitotic sister chromatid cohesion
GO:45876; positive regulation of sister chromatid cohesion
GO:71168; protein localization to chromatin
GO:1990414; replication-born double-strand break repair via sister chromatid exchange
GO:34089; establishment of meiotic sister chromatid cohesion
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:30496; midbody
GO:8278; cohesin complex
GO:5737; cytoplasm
GO:16020; membrane
GO:5856; cytoskeleton
GO:5829; cytosol
GO:775; chromosome, centromeric region
GO:785; chromatin
GO:794; condensed nuclear chromosome
GO:922; spindle pole
GO:16363; nuclear matrix
GO:795; synaptonemal complex
GO:34991; nuclear meiotic cohesin complex
GO:34990; nuclear mitotic cohesin complex
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:3682; chromatin binding
Hide GO terms

Homologs of RAD21 in Model Organisms

Danio rerio
rad21a
Drosophila melanogaster
vtd
Mus musculus
Rad21
Rattus norvegicus
Rad21

In other databases

CellAge gene expression
  • This gene is present as RAD21

External links

OMIM
606462
Ensembl
ENSG00000164754
Entrez Gene
5885
UniGene
81848
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RAD21
GeneCards
RAD21