Cell Senescence Entries for RAD23B

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Comegna et al. (2014) Identification of miR-494 direct targets involved in senescence of human diploid fibroblasts. FASEB J 28(8)3720-33 (PubMed)

RAD23B Gene Information

HGNC symbol
RAD23B 
Aliases
HHR23B; HR23B; P58 
Common name
RAD23 homolog B, nucleotide excision repair protein 
Entrez Id
5887
Description
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011].

RAD23B Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:32434; regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:6289; nucleotide-excision repair
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:7283; spermatogenesis
GO:98761; cellular response to interleukin-7
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:502; proteasome complex
GO:71942; XPC complex
Function: GO:5515; protein binding
GO:3684; damaged DNA binding
GO:31593; polyubiquitin modification-dependent protein binding
GO:43130; ubiquitin binding
GO:70628; proteasome binding
GO:3697; single-stranded DNA binding
GO:976; transcription cis-regulatory region binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140612; DNA damage sensor activity
Hide GO terms

Homologs of RAD23B in Model Organisms

Danio rerio
rad23b
Mus musculus
Rad23b
Rattus norvegicus
Rad23b

In other databases

LongevityMap
  • This gene is present as RAD23B

External links

OMIM
600062
Ensembl
ENSG00000119318
Entrez Gene
5887
UniGene
521640
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RAD23B
GeneCards
RAD23B