Cell Senescence Entries for RAF1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Zhu et al. (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 12(19)2997-3007 (PubMed)

RAF1 Gene Information

HGNC symbol
RAF1 
Aliases
c-Raf; CRAF; Raf-1 
Common name
Raf-1 proto-oncogene, serine/threonine kinase 
Entrez Id
5894
Description
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].

RAF1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:1934; positive regulation of protein phosphorylation
GO:1902531; regulation of intracellular signal transduction
GO:16310; phosphorylation
GO:42981; regulation of apoptotic process
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:45595; regulation of cell differentiation
GO:31333; negative regulation of protein-containing complex assembly
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:165; MAPK cascade
GO:8285; negative regulation of cell population proliferation
GO:42060; wound healing
GO:43410; positive regulation of MAPK cascade
GO:6915; apoptotic process
GO:2000145; regulation of cell motility
GO:7190; activation of adenylate cyclase activity
GO:35023; regulation of Rho protein signal transduction
GO:1678; cellular glucose homeostasis
GO:30154; cell differentiation
GO:30878; thyroid gland development
GO:35019; somatic stem cell population maintenance
GO:35773; insulin secretion involved in cellular response to glucose stimulus
GO:35994; response to muscle stretch
GO:45104; intermediate filament cytoskeleton organization
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48011; neurotrophin TRK receptor signaling pathway
GO:48538; thymus development
GO:60324; face development
GO:71550; death-inducing signaling complex assembly
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5794; Golgi apparatus
GO:5741; mitochondrial outer membrane
GO:31143; pseudopodium
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:4709; MAP kinase kinase kinase activity
GO:31267; small GTPase binding
Hide GO terms

Homologs of RAF1 in Model Organisms

Danio rerio
raf1b
Mus musculus
Raf1
Rattus norvegicus
Raf1

In other databases

LongevityMap
  • This gene is present as RAF1

External links

OMIM
164760
Ensembl
ENSG00000132155
Entrez Gene
5894
UniGene
159130
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RAF1
GeneCards
RAF1