The RAN gene and its putative association with human ageing

Cell Senescence Entries for RAN

Cell Types: Lung fibroblast
Cell Lines: TIG-1
Cancer Cell?: No
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Nagai et al. (2013) Downregulation of the small GTPase ras-related nuclear protein accelerates cellular ageing. Biochim Biophys Acta 1830(3)2813-9 (PubMed)

RAN Gene Information

HGNC symbol: RAN
Aliases: ARA24; Gsp1; TC4
Common name: RAN, member RAS oncogene family
Entrez Id: 5901
Description: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008].

RAN Ontologies

Gene Ontology

Process:

GO:15031; protein transport
GO:6913; nucleocytoplasmic transport
GO:7049; cell cycle
GO:51301; cell division
GO:6259; DNA metabolic process
GO:54; ribosomal subunit export from nucleus
GO:6606; protein import into nucleus
GO:7052; mitotic spindle organization
GO:46039; GTP metabolic process
GO:278; mitotic cell cycle
GO:32092; positive regulation of protein binding
GO:55; ribosomal large subunit export from nucleus
GO:56; ribosomal small subunit export from nucleus
GO:6611; protein export from nucleus
GO:70; mitotic sister chromatid segregation
GO:16032; viral process
GO:35281; pre-miRNA export from nucleus
GO:42307; positive regulation of protein import into nucleus
GO:61015; snRNA import into nucleus
GO:1902570; protein localization to nucleolus

Cellular component:

GO:5634; nucleus
GO:5654; nucleoplasm
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5814; centriole
GO:5635; nuclear envelope
GO:5829; cytosol
GO:785; chromatin
GO:5730; nucleolus
GO:5643; nuclear pore
GO:42470; melanosome
GO:55037; recycling endosome
GO:30496; midbody
GO:70062; extracellular exosome
GO:42565; RNA nuclear export complex

Function:

GO:166; nucleotide binding
GO:3924; GTPase activity
GO:5525; GTP binding
GO:5515; protein binding
GO:3723; RNA binding
GO:46872; metal ion binding
GO:287; magnesium ion binding
GO:3682; chromatin binding
GO:45296; cadherin binding
GO:19003; GDP binding
GO:46982; protein heterodimerization activity
GO:70883; pre-miRNA binding
GO:5049; nuclear export signal receptor activity

Hide GO terms

Homologs of RAN in Model Organisms

Caenorhabditis elegans: ran-1
Danio rerio: ran
Drosophila melanogaster: ran
Mus musculus: Ran
Rattus norvegicus: Ran
Saccharomyces cerevisiae: GSP2
Schizosaccharomyces pombe: spi1

Cell Senescence Entries for RAN

RAN Gene Information

RAN Ontologies

Homologs of RAN in Model Organisms

External links