Cell Senescence Entries for RAP1GAP

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)

RAP1GAP Gene Information

HGNC symbol
RAP1GAP 
Aliases
KIAA0474; RAP1GA1; RAP1GAP1; RAP1GAPII 
Common name
RAP1 GTPase activating protein 
Entrez Id
5909
Description
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011].

RAP1GAP Ontologies

Gene Ontology
Process: GO:50790; regulation of catalytic activity
GO:51056; regulation of small GTPase mediated signal transduction
GO:7165; signal transduction
GO:45665; negative regulation of neuron differentiation
GO:1904425; negative regulation of GTP binding
GO:1904442; negative regulation of thyroid gland epithelial cell proliferation
GO:1990792; cellular response to glial cell derived neurotrophic factor
GO:90630; activation of GTPase activity
GO:43547; positive regulation of GTPase activity
GO:43087; regulation of GTPase activity
GO:2250; adaptive immune response
GO:1903697; negative regulation of microvillus assembly
Cellular component: GO:16020; membrane
GO:5794; Golgi apparatus
GO:5829; cytosol
GO:139; Golgi membrane
GO:5769; early endosome
GO:30424; axon
GO:30425; dendrite
GO:43025; neuronal cell body
GO:5737; cytoplasm
Function: GO:5096; GTPase activator activity
GO:30695; GTPase regulator activity
GO:42803; protein homodimerization activity
GO:3924; GTPase activity
GO:5515; protein binding
GO:31267; small GTPase binding
Hide GO terms

Homologs of RAP1GAP in Model Organisms

Danio rerio
rap1gap
Mus musculus
Rap1gap
Rattus norvegicus
Rap1gap

External links

OMIM
600278
Ensembl
ENSG00000076864
Entrez Gene
5909
UniGene
148178
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RAP1GAP
GeneCards
RAP1GAP