Cell Senescence Entries for RARB

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Lee et al. (1995) Cellular aging and transformation suppression: a role for retinoic acid receptor beta 2. Exp Cell Res 218(1)296-304 (PubMed)

RARB Gene Information

HGNC symbol
RARB 
Aliases
HAP; NR1B2; RRB2 
Common name
retinoic acid receptor beta 
Entrez Id
5915
Description
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014].

RARB Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:48384; retinoic acid receptor signaling pathway
GO:122; negative regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:7165; signal transduction
GO:9755; hormone-mediated signaling pathway
GO:48566; embryonic digestive tract development
GO:1657; ureteric bud development
GO:2068; glandular epithelial cell development
GO:3417; growth plate cartilage development
GO:8285; negative regulation of cell population proliferation
GO:21756; striatum development
GO:22008; neurogenesis
GO:32331; negative regulation of chondrocyte differentiation
GO:35116; embryonic hindlimb morphogenesis
GO:35264; multicellular organism growth
GO:43065; positive regulation of apoptotic process
GO:43068; positive regulation of programmed cell death
GO:48048; embryonic eye morphogenesis
GO:55012; ventricular cardiac muscle cell differentiation
GO:60348; bone development
GO:61037; negative regulation of cartilage development
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5737; cytoplasm
GO:785; chromatin
Function: GO:3677; DNA binding
GO:8270; zinc ion binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:46872; metal ion binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
Hide GO terms

Homologs of RARB in Model Organisms

Mus musculus
Rarb
Rattus norvegicus
Rarb

In other databases

LongevityMap
  • This gene is present as RARB

External links

OMIM
180220
Ensembl
ENSG00000077092
Entrez Gene
5915
UniGene
581530
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RARB
GeneCards
RARB