Cell Senescence Entries for RB1

Cell Types
Osteoblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Kansara et al. (2014) Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation. J Clin Invest 123(12)5351-60 (PubMed)

RB1 Gene Information

HGNC symbol
RB1 
Aliases
OSRC; PPP1R130; RB 
Common name
RB transcriptional corepressor 1 
Entrez Id
5925
Description
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008].

RB1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6357; regulation of transcription by RNA polymerase II
GO:6325; chromatin organization
GO:51726; regulation of cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:6355; regulation of transcription, DNA-templated
GO:82; G1/S transition of mitotic cell cycle
GO:122; negative regulation of transcription by RNA polymerase II
GO:1558; regulation of cell growth
GO:1894; tissue homeostasis
GO:2062; chondrocyte differentiation
GO:3180; aortic valve morphogenesis
GO:6915; apoptotic process
GO:7283; spermatogenesis
GO:7346; regulation of mitotic cell cycle
GO:8285; negative regulation of cell population proliferation
GO:10629; negative regulation of gene expression
GO:30182; neuron differentiation
GO:30308; negative regulation of cell growth
GO:31175; neuron projection development
GO:32869; cellular response to insulin stimulus
GO:34349; glial cell apoptotic process
GO:35914; skeletal muscle cell differentiation
GO:42551; neuron maturation
GO:43353; enucleate erythrocyte differentiation
GO:45651; positive regulation of macrophage differentiation
GO:45786; negative regulation of cell cycle
GO:45879; negative regulation of smoothened signaling pathway
GO:45930; negative regulation of mitotic cell cycle
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48565; digestive tract development
GO:48667; cell morphogenesis involved in neuron differentiation
GO:50680; negative regulation of epithelial cell proliferation
GO:50728; negative regulation of inflammatory response
GO:51146; striated muscle cell differentiation
GO:51301; cell division
GO:51402; neuron apoptotic process
GO:71466; cellular response to xenobiotic stimulus
GO:71901; negative regulation of protein serine/threonine kinase activity
GO:71930; negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:97284; hepatocyte apoptotic process
GO:120163; negative regulation of cold-induced thermogenesis
GO:1902948; negative regulation of tau-protein kinase activity
GO:1903055; positive regulation of extracellular matrix organization
GO:1903944; negative regulation of hepatocyte apoptotic process
GO:1904028; positive regulation of collagen fibril organization
GO:1904761; negative regulation of myofibroblast differentiation
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:2001234; negative regulation of apoptotic signaling pathway
GO:30154; cell differentiation
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:6338; chromatin remodeling
GO:6469; negative regulation of protein kinase activity
GO:7265; Ras protein signal transduction
GO:45445; myoblast differentiation
GO:2000679; positive regulation of transcription regulatory region DNA binding
GO:31134; sister chromatid biorientation
GO:31507; heterochromatin assembly
GO:34088; maintenance of mitotic sister chromatid cohesion
GO:43550; regulation of lipid kinase activity
GO:45842; positive regulation of mitotic metaphase/anaphase transition
GO:71459; protein localization to chromosome, centromeric region
GO:71922; regulation of cohesin loading
GO:90230; regulation of centromere complex assembly
GO:8150; biological_process
Cellular component: GO:5634; nucleus
GO:43229; intracellular organelle
GO:16605; PML body
GO:5667; transcription regulator complex
GO:5819; spindle
GO:35189; Rb-E2F complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:16514; SWI/SNF complex
GO:8024; cyclin/CDK positive transcription elongation factor complex
GO:61793; chromatin lock complex
GO:5575; cellular_component
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:19899; enzyme binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:140297; DNA-binding transcription factor binding
GO:42802; identical protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:51219; phosphoprotein binding
GO:19900; kinase binding
GO:97718; disordered domain specific binding
GO:3714; transcription corepressor activity
GO:61676; importin-alpha family protein binding
GO:3674; molecular_function
Hide GO terms

Homologs of RB1 in Model Organisms

Danio rerio
rb1
Mus musculus
Rb1
Rattus norvegicus
Rb1

In other databases

GenAge human genes
  • This gene is present as RB1

External links

OMIM
614041
Ensembl
ENSG00000139687
Entrez Gene
5925
UniGene
408528
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RB1
GeneCards
RB1