Cell Senescence Entries for RBL2

Cell Types
Breast cancer, Colon cancer, Glioblastoma, Osteosarcoma
Cell Lines
A172, HCT116, MCF-7, U2OS, U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Helmbold et al. (2009) Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence. Oncogene 28(39)3456-67 (PubMed)

RBL2 Gene Information

HGNC symbol
RBL2 
Aliases
p130; Rb2 
Common name
RB transcriptional corepressor like 2 
Entrez Id
5934
Description

RBL2 Ontologies

Gene Ontology
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:51726; regulation of cell cycle
GO:51302; regulation of cell division
GO:7049; cell cycle
GO:6325; chromatin organization
GO:30154; cell differentiation
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:10629; negative regulation of gene expression
GO:43550; regulation of lipid kinase activity
Cellular component: GO:5667; transcription regulator complex
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5694; chromosome
GO:70062; extracellular exosome
GO:785; chromatin
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1990841; promoter-specific chromatin binding
Hide GO terms

Homologs of RBL2 in Model Organisms

Danio rerio
rbl2
Drosophila melanogaster
Rbf
Mus musculus
Rbl2
Rattus norvegicus
Rbl2

External links

OMIM
180203
Ensembl
ENSG00000103479
Entrez Gene
5934
UniGene
513609
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RBL2
GeneCards
RBL2