Cell Senescence Entries for RBM39
- Cell Types
- Foreskin fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Kumar P et al. (2015) Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife 3(2)117-26 (PubMed)
RBM39 Gene Information
- HGNC symbol
- RBM39
- Aliases
- CAPER; CAPERalpha; CC1.3; fSAP59; HCC1; RNPC2
- Common name
- RNA binding motif protein 39
- Entrez Id
- 9584
- Description
- This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Aug 2011].
RBM39 Ontologies
- Gene Ontology
-
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:6396; RNA processing
GO:48024; regulation of mRNA splicing, via spliceosome
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:15630; microtubule cytoskeleton
GO:34451; centriolar satellite
Hide GO termsFunction: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5515; protein binding
GO:50733; RS domain binding
Homologs of RBM39 in Model Organisms
External links
- OMIM
- 604739
- Ensembl
- ENSG00000131051
- Entrez Gene
- 9584
- UniGene
- 731837
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RBM39
- GeneCards
- RBM39