The RBPJ gene and its putative association with human ageing

Cell Types

Esophageal keratinocyte

Cell Lines

EPC1-hTERT, EPC2-hTERT

Cancer Cell?

No

Method

Knockdown

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Kagawa et al. (2015) Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene 34(18)2347-59 (PubMed)

HGNC symbol

RBPJ

Aliases

CBF1; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJK; RBPSUH; SUH

Common name

recombination signal binding protein for immunoglobulin kappa J region

Entrez Id

3516

Description

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013].

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:45892; negative regulation of transcription, DNA-templated
GO:7219; Notch signaling pathway
GO:120163; negative regulation of cold-induced thermogenesis
GO:122; negative regulation of transcription by RNA polymerase II
GO:30513; positive regulation of BMP signaling pathway
GO:3151; outflow tract morphogenesis
GO:1525; angiogenesis
GO:36302; atrioventricular canal development
GO:30279; negative regulation of ossification
GO:1837; epithelial to mesenchymal transition
GO:3198; epithelial to mesenchymal transition involved in endocardial cushion formation
GO:61314; Notch signaling involved in heart development
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:2000138; positive regulation of cell proliferation involved in heart morphogenesis
GO:3214; cardiac left ventricle morphogenesis
GO:3222; ventricular trabecula myocardium morphogenesis
GO:35912; dorsal aorta morphogenesis
GO:3160; endocardium morphogenesis
GO:3256; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:61419; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:7221; positive regulation of transcription of Notch receptor target
GO:60716; labyrinthine layer blood vessel development
GO:72554; blood vessel lumenization
GO:97101; blood vessel endothelial cell fate specification
GO:1901186; positive regulation of ERBB signaling pathway
GO:1901189; positive regulation of ephrin receptor signaling pathway
GO:1756; somitogenesis
GO:1974; blood vessel remodeling
GO:2437; inflammatory response to antigenic stimulus
GO:3139; secondary heart field specification
GO:3157; endocardium development
GO:3176; aortic valve development
GO:3177; pulmonary valve development
GO:6959; humoral immune response
GO:7507; heart development
GO:8284; positive regulation of cell population proliferation
GO:8285; negative regulation of cell population proliferation
GO:9912; auditory receptor cell fate commitment
GO:9957; epidermal cell fate specification
GO:10468; regulation of gene expression
GO:21983; pituitary gland development
GO:30097; hemopoiesis
GO:30182; neuron differentiation
GO:30183; B cell differentiation
GO:30216; keratinocyte differentiation
GO:35019; somatic stem cell population maintenance
GO:42127; regulation of cell population proliferation
GO:42742; defense response to bacterium
GO:43011; myeloid dendritic cell differentiation
GO:45165; cell fate commitment
GO:45596; negative regulation of cell differentiation
GO:48505; regulation of timing of cell differentiation
GO:48733; sebaceous gland development
GO:48820; hair follicle maturation
GO:48844; artery morphogenesis
GO:60412; ventricular septum morphogenesis
GO:60486; club cell differentiation
GO:60844; arterial endothelial cell fate commitment
GO:1901297; positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:785; chromatin
GO:17053; transcription repressor complex
GO:2193; MAML1-RBP-Jkappa- ICN1 complex
GO:5667; transcription regulator complex

Function:

GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:3682; chromatin binding
GO:47485; protein N-terminus binding

Hide GO terms

Caenorhabditis elegans

lag-1

Danio rerio

rbpja

Drosophila melanogaster

Su(H)

Mus musculus

Rbpj

Rattus norvegicus

Rbpj

Schizosaccharomyces pombe