Cell Senescence Entries for RCC1
- Cell Types
- Cervical cancer, Foreskin fibroblast
- Cell Lines
- HeLa, HFF-1
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cekan et al. (2017) RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. Mol Biol Cell 27(8)1346-57 (PubMed)
RCC1 Gene Information
- HGNC symbol
- RCC1
- Aliases
- CHC1
- Common name
- regulator of chromosome condensation 1
- Entrez Id
- 1104
- Description
RCC1 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:50790; regulation of catalytic activity
GO:51301; cell division
GO:7059; chromosome segregation
GO:7052; mitotic spindle organization
GO:82; G1/S transition of mitotic cell cycle
GO:51225; spindle assembly
GO:7088; regulation of mitotic nuclear division
GO:7084; mitotic nuclear membrane reassembly
GO:16032; viral process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:31965; nuclear membrane
GO:785; chromatin
GO:5694; chromosome
GO:32991; protein-containing complex
GO:794; condensed nuclear chromosome
Hide GO termsFunction: GO:3677; DNA binding
GO:5085; guanyl-nucleotide exchange factor activity
GO:5515; protein binding
GO:3682; chromatin binding
GO:42393; histone binding
GO:46982; protein heterodimerization activity
GO:31492; nucleosomal DNA binding
GO:43199; sulfate binding
GO:31267; small GTPase binding
GO:31491; nucleosome binding
Homologs of RCC1 in Model Organisms
- Caenorhabditis elegans
- ran-3
- Danio rerio
- rcc1
- Drosophila melanogaster
- Bj1
- Mus musculus
- Rcc1
- Rattus norvegicus
- Rcc1
- Saccharomyces cerevisiae
- SRM1
External links
- OMIM
- 179710
- Ensembl
- ENSG00000180198
- Entrez Gene
- 1104
- UniGene
- 469723
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RCC1
- GeneCards
- RCC1