Cell Senescence Entries for RECK

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Miki et al. (2010) The ß1-integrin-dependent function of RECK in physiologic and tumor angiogenesis. Mol Cancer Res 8(5)665-76 (PubMed)

RECK Gene Information

HGNC symbol
RECK 
Aliases
hRECK; ST15 
Common name
reversion inducing cysteine rich protein with kazal motifs 
Entrez Id
8434
Description
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].

RECK Ontologies

Gene Ontology
Process: GO:16055; Wnt signaling pathway
GO:10466; negative regulation of peptidase activity
GO:30198; extracellular matrix organization
GO:30336; negative regulation of cell migration
GO:2040; sprouting angiogenesis
GO:1955; blood vessel maturation
GO:7566; embryo implantation
GO:35115; embryonic forelimb morphogenesis
GO:45765; regulation of angiogenesis
GO:60070; canonical Wnt signaling pathway
GO:90210; regulation of establishment of blood-brain barrier
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:1904684; negative regulation of metalloendopeptidase activity
Cellular component: GO:16020; membrane
GO:5886; plasma membrane
GO:31225; anchored component of membrane
GO:5576; extracellular region
GO:1990909; Wnt signalosome
Function: GO:5515; protein binding
GO:4867; serine-type endopeptidase inhibitor activity
GO:30414; peptidase inhibitor activity
GO:8191; metalloendopeptidase inhibitor activity
GO:4866; endopeptidase inhibitor activity
GO:17147; Wnt-protein binding
GO:1904928; coreceptor activity involved in canonical Wnt signaling pathway
Hide GO terms

Homologs of RECK in Model Organisms

Drosophila melanogaster
Reck
Mus musculus
Reck
Rattus norvegicus
Reck

External links

OMIM
605227
Ensembl
ENSG00000122707
Entrez Gene
8434
UniGene
388918
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RECK
GeneCards
RECK