The RELA gene and its putative association with human ageing

Cell Types

Cervical cancer

Cell Lines

HeLa

Cancer Cell?

Yes

Method

Knockdown

Type of senescence

Stress-induced

Senescence Effect

Induces

Primary Reference

Zhi et al. (2011) NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog 7(4)e1002025 (PubMed)

HGNC symbol

RELA

Aliases

NFKB3; p65

Common name

RELA proto-oncogene, NF-kB subunit

Entrez Id

5970

Description

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:32479; regulation of type I interferon production
GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:51607; defense response to virus
GO:6954; inflammatory response
GO:10033; response to organic substance
GO:19221; cytokine-mediated signaling pathway
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:8284; positive regulation of cell population proliferation
GO:45087; innate immune response
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:71347; cellular response to interleukin-1
GO:71356; cellular response to tumor necrosis factor
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:10628; positive regulation of gene expression
GO:32757; positive regulation of interleukin-8 production
GO:71222; cellular response to lipopolysaccharide
GO:1901223; negative regulation of NIK/NF-kappaB signaling
GO:1902894; negative regulation of pri-miRNA transcription by RNA polymerase II
GO:50727; regulation of inflammatory response
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:2357; defense response to tumor cell
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:70301; cellular response to hydrogen peroxide
GO:70498; interleukin-1-mediated signaling pathway
GO:70555; response to interleukin-1
GO:43620; regulation of DNA-templated transcription in response to stress
GO:71223; cellular response to lipoteichoic acid
GO:1902004; positive regulation of amyloid-beta formation
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:1904996; positive regulation of leukocyte adhesion to vascular endothelial cell
GO:34097; response to cytokine
GO:2000630; positive regulation of miRNA metabolic process
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
GO:10224; response to UV-B
GO:71316; cellular response to nicotine
GO:71354; cellular response to interleukin-6
GO:1904385; cellular response to angiotensin
GO:6968; cellular defense response
GO:50862; positive regulation of T cell receptor signaling pathway
GO:7218; neuropeptide signaling pathway
GO:1901222; regulation of NIK/NF-kappaB signaling
GO:38061; NIK/NF-kappaB signaling
GO:70431; nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:1889; liver development
GO:1942; hair follicle development
GO:6325; chromatin organization
GO:6351; transcription, DNA-templated
GO:6952; defense response
GO:9617; response to bacterium
GO:9887; animal organ morphogenesis
GO:32495; response to muramyl dipeptide
GO:32735; positive regulation of interleukin-12 production
GO:33234; negative regulation of protein sumoylation
GO:35729; cellular response to hepatocyte growth factor stimulus
GO:35994; response to muscle stretch
GO:42177; negative regulation of protein catabolic process
GO:71224; cellular response to peptidoglycan
GO:99527; postsynapse to nucleus signaling pathway
GO:1901522; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:10468; regulation of gene expression

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:71159; NF-kappaB complex
GO:785; chromatin
GO:5654; nucleoplasm
GO:5667; transcription regulator complex
GO:35525; NF-kappaB p50/p65 complex
GO:98978; glutamatergic synapse

Function:

GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:31625; ubiquitin protein ligase binding
GO:42802; identical protein binding
GO:31490; chromatin DNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:42826; histone deacetylase binding
GO:3682; chromatin binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:47485; protein N-terminus binding
GO:42301; phosphate ion binding
GO:140297; DNA-binding transcription factor binding
GO:51059; NF-kappaB binding
GO:140296; general transcription initiation factor binding
GO:19899; enzyme binding
GO:1223; transcription coactivator binding
GO:42277; peptide binding
GO:42805; actinin binding
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:43565; sequence-specific DNA binding
GO:71532; ankyrin repeat binding

Hide GO terms

Danio rerio

rela

Drosophila melanogaster

Dif

Mus musculus

Rela

Rattus norvegicus

Rela

GenAge human genes