Cell Senescence Entries for RELB

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Zhi et al. (2011) NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog 7(4)e1002025 (PubMed)

RELB Gene Information

HGNC symbol
RELB 
Aliases
REL-B 
Common name
RELB proto-oncogene, NF-kB subunit 
Entrez Id
5971
Description

RELB Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:45087; innate immune response
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:6954; inflammatory response
GO:34097; response to cytokine
GO:45944; positive regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:19882; antigen processing and presentation
GO:30098; lymphocyte differentiation
GO:32688; negative regulation of interferon-beta production
GO:38061; NIK/NF-kappaB signaling
GO:42088; T-helper 1 type immune response
GO:43011; myeloid dendritic cell differentiation
GO:45063; T-helper 1 cell differentiation
GO:45892; negative regulation of transcription, DNA-templated
GO:71470; cellular response to osmotic stress
GO:32479; regulation of type I interferon production
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5815; microtubule organizing center
GO:5813; centrosome
GO:785; chromatin
GO:17053; transcription repressor complex
GO:71159; NF-kappaB complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:19901; protein kinase binding
GO:42802; identical protein binding
Hide GO terms

Homologs of RELB in Model Organisms

Mus musculus
Relb
Rattus norvegicus
Relb

External links

OMIM
604758
Ensembl
ENSG00000104856
Entrez Gene
5971
UniGene
654402
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RELB
GeneCards
RELB