Cell Senescence Entries for RHOA

Cell Types
Mammary epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Zhao et al. (2009) Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells. Cancer Res 69(2)483-91 (PubMed)

RHOA Gene Information

HGNC symbol
RHOA 
Aliases
ARH12; ARHA; Rho12; RHOH12 
Common name
ras homolog family member A 
Entrez Id
387
Description
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].

RHOA Ontologies

Gene Ontology
Process: GO:7264; small GTPase mediated signal transduction
GO:7049; cell cycle
GO:30036; actin cytoskeleton organization
GO:51301; cell division
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:44319; wound healing, spreading of cells
GO:1902766; skeletal muscle satellite cell migration
GO:7266; Rho protein signal transduction
GO:32956; regulation of actin cytoskeleton organization
GO:71222; cellular response to lipopolysaccharide
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:16477; cell migration
GO:30334; regulation of cell migration
GO:7015; actin filament organization
GO:8360; regulation of cell shape
GO:34329; cell junction assembly
GO:45198; establishment of epithelial cell apical/basal polarity
GO:21762; substantia nigra development
GO:43149; stress fiber assembly
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:7163; establishment or maintenance of cell polarity
GO:30865; cortical cytoskeleton organization
GO:32467; positive regulation of cytokinesis
GO:60071; Wnt signaling pathway, planar cell polarity pathway
GO:90307; mitotic spindle assembly
GO:31532; actin cytoskeleton reorganization
GO:43931; ossification involved in bone maturation
GO:34446; substrate adhesion-dependent cell spreading
GO:43297; apical junction assembly
GO:50919; negative chemotaxis
GO:43542; endothelial cell migration
GO:71345; cellular response to cytokine stimulus
GO:1904996; positive regulation of leukocyte adhesion to vascular endothelial cell
GO:38027; apolipoprotein A-I-mediated signaling pathway
GO:60193; positive regulation of lipase activity
GO:2000406; positive regulation of T cell migration
GO:51893; regulation of focal adhesion assembly
GO:51496; positive regulation of stress fiber assembly
GO:45666; positive regulation of neuron differentiation
GO:90051; negative regulation of cell migration involved in sprouting angiogenesis
GO:97498; endothelial tube lumen extension
GO:10812; negative regulation of cell-substrate adhesion
GO:31122; cytoplasmic microtubule organization
GO:33688; regulation of osteoblast proliferation
GO:35385; Roundabout signaling pathway
GO:36089; cleavage furrow formation
GO:45792; negative regulation of cell size
GO:61383; trabecula morphogenesis
GO:1903673; mitotic cleavage furrow formation
GO:1905274; regulation of modification of postsynaptic actin cytoskeleton
GO:1990869; cellular response to chemokine
GO:902; cell morphogenesis
GO:1666; response to hypoxia
GO:1822; kidney development
GO:1998; angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:2363; alpha-beta T cell lineage commitment
GO:3100; regulation of systemic arterial blood pressure by endothelin
GO:6357; regulation of transcription by RNA polymerase II
GO:7010; cytoskeleton organization
GO:7155; cell adhesion
GO:7160; cell-matrix adhesion
GO:7519; skeletal muscle tissue development
GO:8064; regulation of actin polymerization or depolymerization
GO:9410; response to xenobiotic stimulus
GO:9612; response to mechanical stimulus
GO:9749; response to glucose
GO:10975; regulation of neuron projection development
GO:10977; negative regulation of neuron projection development
GO:21795; cerebral cortex cell migration
GO:21861; forebrain radial glial cell differentiation
GO:30154; cell differentiation
GO:30307; positive regulation of cell growth
GO:30335; positive regulation of cell migration
GO:30521; androgen receptor signaling pathway
GO:30838; positive regulation of actin filament polymerization
GO:31098; stress-activated protein kinase signaling cascade
GO:33144; negative regulation of intracellular steroid hormone receptor signaling pathway
GO:42476; odontogenesis
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:43200; response to amino acid
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:43366; beta selection
GO:43524; negative regulation of neuron apoptotic process
GO:43525; positive regulation of neuron apoptotic process
GO:45471; response to ethanol
GO:45665; negative regulation of neuron differentiation
GO:45727; positive regulation of translation
GO:45785; positive regulation of cell adhesion
GO:45907; positive regulation of vasoconstriction
GO:45987; positive regulation of smooth muscle contraction
GO:46039; GTP metabolic process
GO:46638; positive regulation of alpha-beta T cell differentiation
GO:48812; neuron projection morphogenesis
GO:50773; regulation of dendrite development
GO:51384; response to glucocorticoid
GO:51924; regulation of calcium ion transport
GO:60548; negative regulation of cell death
GO:70507; regulation of microtubule cytoskeleton organization
GO:71803; positive regulation of podosome assembly
GO:90324; negative regulation of oxidative phosphorylation
GO:1903427; negative regulation of reactive oxygen species biosynthetic process
GO:1904695; positive regulation of vascular associated smooth muscle contraction
GO:1904706; negative regulation of vascular associated smooth muscle cell proliferation
GO:1904753; negative regulation of vascular associated smooth muscle cell migration
GO:1905244; regulation of modification of synaptic structure
GO:2000177; regulation of neural precursor cell proliferation
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5829; cytosol
GO:42995; cell projection
GO:30425; dendrite
GO:71944; cell periphery
GO:5938; cell cortex
GO:30027; lamellipodium
GO:30496; midbody
GO:32154; cleavage furrow
GO:31410; cytoplasmic vesicle
GO:5789; endoplasmic reticulum membrane
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:70062; extracellular exosome
GO:43296; apical junction complex
GO:30667; secretory granule membrane
GO:30054; cell junction
GO:98978; glutamatergic synapse
GO:101003; ficolin-1-rich granule membrane
GO:43197; dendritic spine
GO:98794; postsynapse
GO:31982; vesicle
GO:5768; endosome
GO:5634; nucleus
GO:30424; axon
GO:32587; ruffle membrane
Function: GO:3924; GTPase activity
GO:5525; GTP binding
GO:5515; protein binding
GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:3925; G protein activity
GO:19901; protein kinase binding
GO:17022; myosin binding
GO:19003; GDP binding
GO:19904; protein domain specific binding
GO:51022; Rho GDP-dissociation inhibitor binding
Hide GO terms

Homologs of RHOA in Model Organisms

Danio rerio
rhoab
Mus musculus
Rhoa
Rattus norvegicus
Rhoa

In other databases

LongevityMap
  • This gene is present as RHOA

External links

OMIM
165390
Ensembl
ENSG00000067560
Entrez Gene
387
UniGene
247077
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RHOA
GeneCards
RHOA