Cell Senescence Entries for ROMO1
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Chung et al. (2009) Replicative senescence induced by Romo1-derived reactive oxygen species. J Biol Chem 283(48)33763-71 (PubMed)
ROMO1 Gene Information
- HGNC symbol
- ROMO1
- Aliases
- bA353C18.2; C20orf52; MTGMP
- Common name
- reactive oxygen species modulator 1
- Entrez Id
- 140823
- Description
- The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014].
ROMO1 Ontologies
- Gene Ontology
-
Process: GO:8284; positive regulation of cell population proliferation
GO:50830; defense response to Gram-positive bacterium
GO:42742; defense response to bacterium
GO:50829; defense response to Gram-negative bacterium
GO:2000379; positive regulation of reactive oxygen species metabolic process
GO:61844; antimicrobial humoral immune response mediated by antimicrobial peptide
GO:30150; protein import into mitochondrial matrix
GO:31640; killing of cells of other organism
GO:51838; cytolysis by host of symbiont cells
GO:34614; cellular response to reactive oxygen species
GO:45039; protein insertion into mitochondrial inner membrane
GO:90399; replicative senescence
GO:6886; intracellular protein transport
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5744; TIM23 mitochondrial import inner membrane translocase complex
Hide GO termsFunction: GO:5515; protein binding
GO:3674; molecular_function
Homologs of ROMO1 in Model Organisms
- Caenorhabditis elegans
- rmo-1
- Danio rerio
- romo1
- Drosophila melanogaster
- CG6878
- Mus musculus
- Romo1
- Rattus norvegicus
- Romo1
- Saccharomyces cerevisiae
- MGR2
- Schizosaccharomyces pombe
- mgr2
External links
- OMIM
- 618894
- Ensembl
- ENSG00000125995
- Entrez Gene
- 140823
- UniGene
- 472564
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ROMO1
- GeneCards
- ROMO1