Cell Senescence Entries for RPL11

Cell Types
Osteosarcoma
Cell Lines
U2OS
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Lindström et al. (2011) Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation. PLoS One 5(3)e9578 (PubMed)

RPL11 Gene Information

HGNC symbol
RPL11 
Aliases
L11; uL5 
Common name
ribosomal protein L11 
Entrez Id
6135
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010].

RPL11 Ontologies

Gene Ontology
Process: GO:6412; translation
GO:2181; cytoplasmic translation
GO:6364; rRNA processing
GO:42273; ribosomal large subunit biogenesis
GO:32435; negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:6605; protein targeting
GO:10628; positive regulation of gene expression
GO:34504; protein localization to nucleus
GO:50821; protein stabilization
GO:27; ribosomal large subunit assembly
GO:1901796; regulation of signal transduction by p53 class mediator
GO:1904667; negative regulation of ubiquitin protein ligase activity
GO:2000059; negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435; negative regulation of protein neddylation
GO:32092; positive regulation of protein binding
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5840; ribosome
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
GO:32991; protein-containing complex
GO:22625; cytosolic large ribosomal subunit
GO:22626; cytosolic ribosome
GO:42788; polysomal ribosome
GO:43232; intracellular non-membrane-bounded organelle
Function: GO:3723; RNA binding
GO:3735; structural constituent of ribosome
GO:5515; protein binding
GO:19843; rRNA binding
GO:31625; ubiquitin protein ligase binding
GO:8097; 5S rRNA binding
GO:1990948; ubiquitin ligase inhibitor activity
Hide GO terms

Homologs of RPL11 in Model Organisms

Caenorhabditis elegans
rpl-11.1
Danio rerio
rpl11
Drosophila melanogaster
RpL11
Mus musculus
Rpl11
Rattus norvegicus
Rpl11
Saccharomyces cerevisiae
RPL11B
Schizosaccharomyces pombe
rpl11a

External links

OMIM
604175
Ensembl
ENSG00000142676
Entrez Gene
6135
UniGene
719951
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RPL11
GeneCards
RPL11