Cell Senescence Entries for RPS6KB1

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Yepuri et al. (2013) Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell 11(6)1005-16 (PubMed)
Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Rajapakse et al. (2011) Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol. PLoS One 6(4)e19237 (PubMed)

RPS6KB1 Gene Information

HGNC symbol
RPS6KB1 
Aliases
p70(S6K)-alpha; PS6K; S6K; S6K1; STK14A 
Common name
ribosomal protein S6 kinase B1 
Entrez Id
6198
Description
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].

RPS6KB1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:7165; signal transduction
GO:6417; regulation of translation
GO:18105; peptidyl-serine phosphorylation
GO:48015; phosphatidylinositol-mediated signaling
GO:71363; cellular response to growth factor stimulus
GO:45727; positive regulation of translation
GO:45948; positive regulation of translational initiation
GO:82; G1/S transition of mitotic cell cycle
GO:44539; long-chain fatty acid import into cell
GO:32869; cellular response to insulin stimulus
GO:46627; negative regulation of insulin receptor signaling pathway
GO:45931; positive regulation of mitotic cell cycle
GO:31929; TOR signaling
GO:31667; response to nutrient levels
GO:1662; behavioral fear response
GO:3009; skeletal muscle contraction
GO:7281; germ cell development
GO:7568; aging
GO:7584; response to nutrient
GO:7616; long-term memory
GO:9408; response to heat
GO:9410; response to xenobiotic stimulus
GO:9611; response to wounding
GO:9612; response to mechanical stimulus
GO:9636; response to toxic substance
GO:9749; response to glucose
GO:10033; response to organic substance
GO:10243; response to organonitrogen compound
GO:14070; response to organic cyclic compound
GO:14732; skeletal muscle atrophy
GO:14878; response to electrical stimulus involved in regulation of muscle adaptation
GO:14911; positive regulation of smooth muscle cell migration
GO:16477; cell migration
GO:32496; response to lipopolysaccharide
GO:32868; response to insulin
GO:32870; cellular response to hormone stimulus
GO:33574; response to testosterone
GO:33762; response to glucagon
GO:34612; response to tumor necrosis factor
GO:43200; response to amino acid
GO:43201; response to leucine
GO:43434; response to peptide hormone
GO:43491; protein kinase B signaling
GO:45471; response to ethanol
GO:46324; regulation of glucose import
GO:48633; positive regulation of skeletal muscle tissue growth
GO:48661; positive regulation of smooth muscle cell proliferation
GO:51384; response to glucocorticoid
GO:71346; cellular response to interferon-gamma
GO:71407; cellular response to organic cyclic compound
GO:71549; cellular response to dexamethasone stimulus
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:30054; cell junction
GO:45202; synapse
GO:43005; neuron projection
GO:5829; cytosol
GO:9986; cell surface
GO:48471; perinuclear region of cytoplasm
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:5524; ATP binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4711; ribosomal protein S6 kinase activity
GO:30165; PDZ domain binding
GO:42277; peptide binding
GO:42802; identical protein binding
GO:51721; protein phosphatase 2A binding
Hide GO terms

Homologs of RPS6KB1 in Model Organisms

Danio rerio
rps6kb1b
Mus musculus
Rps6kb1
Rattus norvegicus
Rps6kb1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Rps6kb1
LongevityMap

External links

OMIM
608938
Ensembl
ENSG00000108443
Entrez Gene
6198
UniGene
463642
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RPS6KB1
GeneCards
RPS6KB1