Cell Senescence Entries for RPTOR

Cell Types
Nucleus pulposus
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ito et al. (2018) Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction. Osteoarthritis Cartilage 25(12)2134-2146 (PubMed)

RPTOR Gene Information

HGNC symbol
RPTOR 
Aliases
KIAA1303; KOG1; Mip1; raptor 
Common name
regulatory associated protein of MTOR complex 1 
Entrez Id
57521
Description
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

RPTOR Ontologies

Gene Ontology
Process: GO:31929; TOR signaling
GO:43086; negative regulation of catalytic activity
GO:9410; response to xenobiotic stimulus
GO:32147; activation of protein kinase activity
GO:71230; cellular response to amino acid stimulus
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:1558; regulation of cell growth
GO:8361; regulation of cell size
GO:32008; positive regulation of TOR signaling
GO:35176; social behavior
GO:31669; cellular response to nutrient levels
GO:10506; regulation of autophagy
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:9267; cellular response to starvation
GO:30307; positive regulation of cell growth
GO:16310; phosphorylation
GO:38202; TORC1 signaling
GO:45945; positive regulation of transcription by RNA polymerase III
GO:71233; cellular response to leucine
GO:1900087; positive regulation of G1/S transition of mitotic cell cycle
GO:1938; positive regulation of endothelial cell proliferation
GO:10800; positive regulation of peptidyl-threonine phosphorylation
GO:42325; regulation of phosphorylation
GO:6974; cellular response to DNA damage stimulus
GO:10507; negative regulation of autophagy
GO:45821; positive regulation of glycolytic process
GO:46889; positive regulation of lipid biosynthetic process
GO:71456; cellular response to hypoxia
GO:71470; cellular response to osmotic stress
GO:1905857; positive regulation of pentose-phosphate shunt
Cellular component: GO:31931; TORC1 complex
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5765; lysosomal membrane
GO:5764; lysosome
GO:10494; cytoplasmic stress granule
GO:30425; dendrite
GO:43025; neuronal cell body
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:44877; protein-containing complex binding
GO:71889; 14-3-3 protein binding
GO:30674; protein-macromolecule adaptor activity
GO:1002; RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:1003; RNA polymerase III type 2 promoter sequence-specific DNA binding
GO:1006; RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:1156; TFIIIC-class transcription factor complex binding
GO:30291; protein serine/threonine kinase inhibitor activity
GO:30295; protein kinase activator activity
Hide GO terms

Homologs of RPTOR in Model Organisms

Caenorhabditis elegans
daf-15
Danio rerio
rptor
Drosophila melanogaster
raptor
Mus musculus
Rptor
Rattus norvegicus
Rptor
Saccharomyces cerevisiae
KOG1
Schizosaccharomyces pombe
mip1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-15
LongevityMap
  • This gene is present as RPTOR

External links

OMIM
607130
Ensembl
ENSG00000141564
Entrez Gene
57521
UniGene
133044
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RPTOR
GeneCards
RPTOR