Cell Senescence Entries for RRM2B

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kuo et al. (2013) RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence. Sci Rep 2(2)822 (PubMed)

RRM2B Gene Information

HGNC symbol
RRM2B 
Aliases
p53R2 
Common name
ribonucleotide reductase regulatory TP53 inducible subunit M2B 
Entrez Id
50484
Description
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].

RRM2B Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6260; DNA replication
GO:9263; deoxyribonucleotide biosynthetic process
GO:6264; mitochondrial DNA replication
GO:9185; ribonucleoside diphosphate metabolic process
GO:9265; 2'-deoxyribonucleotide biosynthetic process
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:70318; positive regulation of G0 to G1 transition
GO:1822; kidney development
GO:3014; renal system process
GO:6979; response to oxidative stress
GO:9200; deoxyribonucleoside triphosphate metabolic process
GO:14075; response to amine
GO:1902254; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:731; DNA synthesis involved in DNA repair
GO:55086; nucleobase-containing small molecule metabolic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:5971; ribonucleoside-diphosphate reductase complex
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:4748; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Hide GO terms

Homologs of RRM2B in Model Organisms

Drosophila melanogaster
RnrS
Mus musculus
Rrm2b
Rattus norvegicus
Rrm2b
Saccharomyces cerevisiae
RNR2
Schizosaccharomyces pombe
suc22

In other databases

CellAge gene expression
  • This gene is present as RRM2B

External links

OMIM
604712
Ensembl
ENSG00000048392
Entrez Gene
50484
UniGene
512592
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RRM2B
GeneCards
RRM2B