Cell Senescence Entries for RTN4
- Cell Types
- Prostate cancer
- Cell Lines
- DU145
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Zhao et al. (2020) Cell fate regulation by reticulon-4 in human prostate cancers. J Cell Physiol 234(7)10372-10385 (PubMed)
RTN4 Gene Information
- HGNC symbol
- RTN4
- Aliases
- ASY; KIAA0886; NOGO; NSP-CL
- Common name
- reticulon 4
- Entrez Id
- 57142
- Description
- This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
RTN4 Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:7399; nervous system development
GO:42981; regulation of apoptotic process
GO:71456; cellular response to hypoxia
GO:61462; protein localization to lysosome
GO:1902430; negative regulation of amyloid-beta formation
GO:71786; endoplasmic reticulum tubular network organization
GO:71787; endoplasmic reticulum tubular network formation
GO:50821; protein stabilization
GO:34165; positive regulation of toll-like receptor 9 signaling pathway
GO:30517; negative regulation of axon extension
GO:7413; axonal fasciculation
GO:51292; nuclear pore complex assembly
GO:1990809; endoplasmic reticulum tubular network membrane organization
GO:10634; positive regulation of epithelial cell migration
GO:21801; cerebral cortex radial glia-guided migration
GO:30308; negative regulation of cell growth
GO:33601; positive regulation of mammary gland epithelial cell proliferation
GO:51897; positive regulation of protein kinase B signaling
GO:1905552; positive regulation of protein localization to endoplasmic reticulum
GO:1905580; positive regulation of ERBB3 signaling pathway
GO:2000172; regulation of branching morphogenesis of a nerve
GO:35441; cell migration involved in vasculogenesis
GO:2001213; negative regulation of vasculogenesis
GO:22009; central nervous system vasculogenesis
GO:1825; blastocyst formation
GO:51960; regulation of nervous system development
GO:60317; cardiac epithelial to mesenchymal transition
GO:90156; cellular sphingolipid homeostasis
GO:45766; positive regulation of angiogenesis
GO:7029; endoplasmic reticulum organization
GO:60907; positive regulation of macrophage cytokine production
GO:2523; leukocyte migration involved in inflammatory response
GO:2000347; positive regulation of hepatocyte proliferation
GO:1905653; positive regulation of artery morphogenesis
GO:1902624; positive regulation of neutrophil migration
GO:30334; regulation of cell migration
GO:35022; positive regulation of Rac protein signal transduction
GO:120078; cell adhesion involved in sprouting angiogenesis
GO:1905523; positive regulation of macrophage migration
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:5635; nuclear envelope
GO:30054; cell junction
GO:30176; integral component of endoplasmic reticulum membrane
GO:98826; endoplasmic reticulum tubular network membrane
GO:71782; endoplasmic reticulum tubular network
GO:14069; postsynaptic density
GO:42995; cell projection
GO:110165; cellular anatomical entity
Hide GO termsFunction: GO:3723; RNA binding
GO:5515; protein binding
GO:45296; cadherin binding
GO:31625; ubiquitin protein ligase binding
GO:42803; protein homodimerization activity
Homologs of RTN4 in Model Organisms
External links
- OMIM
- 604475
- Ensembl
- ENSG00000115310
- Entrez Gene
- 57142
- UniGene
- 637850
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RTN4
- GeneCards
- RTN4